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Recurrrent Cardiovascular deaths cut in half if 10 ng more Vitamin D – meta-analysis Sept 2021

Circulating 25-hydroxy-vitamin D and the risk of cardiovascular diseases. Systematic review and meta-analysis of prospective cohort studies

Nutr Metab Cardiovasc Dis. 2021 Sep 21;S0939-4753(21)00443-9. doi: 10.1016/j.numecd.2021.09.003
Rati Jani 1, Kshemina Mhaskar 2, Thomas Tsiampalis 3, Nigussie A Kassaw 4, Miguel Á M González 5, Demosthenes B Panagiotakos 6

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Cardiovascular category starts with

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Caridovascular Meta-analyses (auto-updated)


Note: The title is my interpretation of the abstract.
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Aims: Circulating vitamin D is linked with the risk of cardiovascular disease (CVD). A meta-analysis has yet to explicitly explore correlation between vitamin D and the risk of CVD incidence and recurrent CVD. This meta-analysis examines the association between 25-hydroxy-vitamin D (25(OH)D) and the risk of CVD incidence (fatal, non-fatal, fatal and non-fatal combined events) and the risk of recurrent CVD (fatal, recurrent, and fatal and recurrent combined events). PROSPERO registration-CRD42021251483.

Data synthesis: A total of 79 studies (46 713 CVD cases in 1 397 831 participants) were included in the meta-analysis, of which 61 studies examined the risk of CVD incidence events, and 18 studies examined risk of recurrent CVD events. The risk of

  • CVD incidence events (RR = 1.34, 95% CI: 1.26-1.43, p < 0.001) and
  • recurrent CVD events (RR = 1.86, 95% CI: 1.46-2.36, p < 0.001)

was higher in the lowest than the highest category of circulating 25(OH)D.

Dose-response analysis reported a linear association for every 10 ng/ml increment of 25(OH)D and

  • non-fatal CVD incidence events (RR = 0.94; 95% CI = 0.89-0.98, p = 0.005),
  • Lower fatal recurrent CVD events (RR = 0.45; 95% CI = 0.32-0.62, p < 0.001) and
  • lower combined recurrent CVD events (RR = 0.80; 95% CI = 0.65-0.97, p = 0.023).

A non-linear association was observed between higher 25(OH)D and lower fatal CVD incidence events (P-nonlinear<0.001), lower combined CVD incidence events (P-nonlinear = 0.001), and lower non-fatal recurrent CVD events (P-nonlinear = 0.044).

Conclusions: The lowest category of circulating 25(OH)D was associated with a higher risk of CVD incidence events and recurrent CVD events.


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