Plasma vitamin D and serum total immunoglobulin E levels in patients with seasonal allergic conjunctivitis
Acta Ophthalmologica Scandinavica Foundation, Article first published online: 25 MAR 2014. DOI: 10.1111/aos.12398
Zeynep Dadaci 1,*, Mehmet Borazan 1, Aysel Kiyici 2 andNursen Oncel Acir 1
* Zeynep Dadaci, MD, Department of Ophthalmology, Mevlana (Rumi) University School of Medicine zdadaci at hotmail.com
Purpose: To evaluate plasma 25-hydroxyvitamin D and serum total immunoglobulin E (IgE) levels in patients with seasonal allergic conjunctivitis (SAC).
This observational case–control study involved 49 patients with SAC without any other ocular and systemic diseases, and 44 consecutive, age- and sex-matched healthy subjects. Plasma 25-hydroxyvitamin D and serum total IgE levels of all subjects were quantified with electrochemiluminescence technique. Results were compared between the groups, and p values of <0.05 were considered as statistically significant.
No significant differences were found between the groups with respect to age (p = 0.41) and sex (p = 0.98).
Plasma vitamin D levels of the
- subjects with SAC (*median 8.03 ng/ml, range 3.00–17.97 ng/ml) were significantly lower than the
- control group (median 10.52 ng/ml, range 3.30–25.92 ng/ml) (p = 0.007).
Serum total IgE levels of
- patients with SAC (median 48.65 IU/ml, range 1.77–812.00 IU/ml) were significantly higher when compared to the
- control group (median 32.49 IU/ml, range 0.14–104.60 IU/ml) (p = 0.003).
We found lower plasma vitamin D levels and higher serum total IgE levels in patients with SAC.
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Plasma vitamin D levels of patients with allergic rhino-conjunctivitis with positive skin prick test.
Am J Rhinol Allergy. 2015 Mar;29(2):46-9. doi: 10.2500/ajra.2015.29.4164.
Yenigun A1, Dadaci Z, Oncel M.
42 patients, average age 26
Vitamin D level: 7 ng if ARC, 13 ng control group
The items in Autoimmune and Infant-Child D are listed here:
- Breastfeeding a child without adding vitamin D increases risk of many food allergies (egg whites in this case) – Jan 2020
- Antibiotics increased the risk of asthma by 47%, and allergies by 25% - Dec 2019
- Low vitamin D newborns getting cows milk formula more likely to get allergies – RCT Oct 2019
- Childhood allergies (Atopy) 4.8 X more likely if low vitamin D in early pregnancy – Aug 2019
- Kawasaki disease (strawberry tongue) not treated by occasional 400 IU of Vitamin D – Feb 2019
- Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency – Jan 2019
- Childhood Food Allergies (UK 1 in 14) – huge recent increase (low vitamin D) - Dec 2018
- Food allergies are associated with Vitamin D thru genes, etc. – March 2018
- Food allergies in children may be due to earlier low Vitamin D, Omega-3 and Zinc – Aug 2017
- T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017
- Infant allergy to cow’s milk will go away if have high levels of vitamin D – Jan 2017
- Food allergies and low vitamin D – thymus may be the connection – June 2016
- Food allergies 6 times higher in South Australia - 2009
- Hypothesis – Australia has highest rate of food allergy due to avoiding the sun – Sept 2015
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
- Too much vitamin D: 1 pcnt increase in infants with food allergy, too little: 500 pcnt increase in children with food allergy - Aug 2015
- Kawasaki disease (strawberry tongue) associated with very low vitamin D – May 2015
- Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014
- Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014
- Pink eye (seasonal allergic conjunctivitis) associated with low vitamin D and high vitamin E – March 2014
- 11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013
- 30 to 40 ng of vitamin D associated with the least peanut allergy – Nov 2012
- High level of maternal vitamin D and infant food allergy – controversy
- Youths with autoimmunity disorders were 2.3 X more likely to be vitamin D deficient – July 2012
- Still unsure of association between vitamin D and asthma and allergies – review April 2012
- Allergy - Overview
- 3X more allergy to peanuts if child born with low UV – Feb 2011
- More childhood allergies when vitamin D is less than 15 ng – Feb 2011
Allergic rhino-conjunctivitis (ARC) and allergic rhinitis are inflammatory diseases that develop through immunoglobulin E in the rhino-ocular mucosa due to allergy. The main symptoms are runny nose, nasal congestion, sneezing, itchy nose, and conjunctivitis.
This study was designed to evaluate plasma 25-hydroxyvitamin D levels in patients with ARC.
This study was planned as a prospective and cross sectional study. This study was performed in a tertiary referral center.
This observational study involved 42 patients with ARC and 35 consecutive, age- and sex-matched healthy subjects. Patients in both groups underwent skin-prick test. Plasma 25-hydroxyvitamin D levels of all subjects were quantified with electrochemiluminescence technique. Results were compared between the groups and p < 0.05 was considered as statistically significant.
Group one included 42 ARC patients (15 male, 27 female, ages between 12 and 43, average age 25.7 ± 8.6); group two included 35 healthy people (15 male, 20 female, ages between 12 and 44, average age 26.9 ± 9.1). Plasma 25-hydroxyvitamin D levels of the subjects with ARC group (7.33 ± 3.61 ng/mL, standard error mean: 0.55, range 3.17-13.68 ng/mL) were significantly lower than the control group (13.37 ± 5.42 ng/mL, standard error mean: 0.91, range 6.84-25.92 ng/mL) (p = 0.010, Independent-Samples test).
We found lower plasma vitamin D levels in patients with ARC when compared with the control group.