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COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020

Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19

Journal of Endocrinological Investigation 09 August 2020, https://doi.org/10.1007/s40618-020-01370-x
G. E. Carpagnano, V. Di Lecce, V. N. Quaranta, A. Zito, E. Buonamico, E. Capozza, A. Palumbo, G. Di Gioia, V. N. Valerio & O. Resta

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Items in both categories Breathing and Virus are listed here:


Breathing category starts with the following

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The results in this study could be due to

  • ARDS ==> low vitamin D ==> Death
  • Low Vitamin D ==> COVID-19 ==> ARDS ==> Death

Note only at precisely 10 days was the Risk factor 10X
If was generally <2X

Note: This study chose to exclude those with the worst COVID-19 conditions = intubation
The worst of the potential "severely deficient" aren't included in the % and outcomes.
These excluded patients might be the ones with the worst inflammatory reaction (cytokine storm).

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Purpose
Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world is in the grip of the Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease severity. In consideration of the role of vitamin D in the immune system, aim of this study was to analyse vitamin D levels in patients with acute respiratory failure due to COVID-19 and to assess any correlations with disease severity and prognosis.

Methods
In this retrospective, observational study, we analysed demographic, clinical and laboratory data of 42 patients with acute respiratory failure due to COVID-19, treated in Respiratory Intermediate Care Unit (RICU) of the Policlinic of Bari from March, 11 to April 30, 2020.

Results
Eighty one percent of patients had hypovitaminosis D. Based on vitamin D levels, the population was stratified into four groups: no hypovitaminosis D, insufficiency, moderate deficiency, and severe deficiency. No differences regarding demographic and clinical characteristics were found. A survival analysis highlighted that, after 10 days of hospitalization, severe vitamin D deficiency patients had a 50% mortality probability, while those with vitamin D ≥ 10 ng/mL had a 5% mortality risk (p = 0.019).

Conclusions
High prevalence of hypovitaminosis D was found in COVID-19 patients with acute respiratory failure, treated in a RICU. Patients with severe vitamin D deficiency had a significantly higher mortality risk. Severe vitamin D deficiency may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes.


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