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Air Pollution reduces Vitamin D


Air pollution decreases vitamin D:

  1. Pollution reduces the amount of time that people are outdoors
  2. Pollution attenuates the amount of UVB getting to the skin (by only a few percent)
  3. Pollution is often associated with hot temperatures, another reason to not go outdoors
  4. Irritation/Inflammation of lungs may consume vitamin D

See also VitaminDWiki


Decrease in UVB: ratio of polluted sky in Tokyo vs clear sky in New Zealand
Note: Tokyo is much closer to equator, so should have much more UVB than NZ
Note: You can ignore the blue = winter line
Image


Vitamin D reduces air polution cell damage by autophagy (disassemble the damaged cells) - Jan 2019

Vitamin D protects against particles-caused lung injury through induction of autophagy in an Nrf2-dependent manner
Environ Toxicol. 2019 Jan 30. doi: 10.1002/tox.22726.
Tao S1,2, Zhang H2, Xue L2, Jiang X1, Wang H1, Li B2, Tian H2, Zhang Z2.
1 Department of Endocrinology and Nephrology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing, China.
2 Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease, School of Public Health, Soochow University, Suzhou, China.

Fine particulate matter is a well-known air pollutant threatening public health. Studies have confirmed long-term exposure to the particles could decrease the pulmonary function, induce asthma exacerbation, and chronic obstructive pulmonary disease, as well as increase the incidence and mortality of lung cancer. A clinical study has explored that the prevalence and risks of vitamin D (VD) deficiency in various chronic disease and toxins induced tissue damage. Our current study aimed to explore the mechanism and further therapeutic potential of VD administration to ameliorate fine particles exposure induced pulmonary damage in vivo and in vitro. To elucidate the effects and mechanisms of VD in particles-induced pulmonary damage, a murine model was established with fine particles intratracheal instillation along with VD intramuscular injection. Our study demonstrated that treatment with VD attenuated particles-induced pulmonary damage and promoted tissue repair by repressing of TGFβ1 signaling pathway and upregulation of MMP9 expression. VD treatment could also regulate the autophagy-related signals along with activation of Nrf2 transcription factor. Furthermore, the results from the in vitro study demonstrated that VD protected against particles-induced cells' damage through the induction of autophagy in an Nrf2-dependent manner. VD treatment caused the degradation of P62 and its bound Keap1, which decreased the Nrf2 ubiquitination and increasing its protein stability. Our work explored a novel potential mechanism in the protection of VD in particles-induced pulmonary injury and tissue repair, and could further bring insights into exploring antifine particles exposure caused inflammation among other natural products and contributes to inflammation disease medical therapies.


Vitamin D treated particulate matter health problems - Aug 2018

Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter
PLoS One. 2018 Aug 29;13(8):e0200040. doi: 10.1371/journal.pone.0200040. eCollection 2018.
Pfeffer PE1,2, Lu H1, Mann EH1, Chen YH1, Ho TR1, Cousins DJ1,3, Corrigan C1, Kelly FJ4, Mudway IS4, Hawrylowicz CM1.
.
BACKGROUND: Particulate matter (PM) pollutant exposure, which induces oxidative stress and inflammation, and vitamin D insufficiency, which compromises immune regulation, are detrimental in asthma.

OBJECTIVES: Mechanistic cell culture experiments were undertaken to ascertain whether vitamin D abrogates PM-induced inflammatory responses of human bronchial epithelial cells (HBECs) through enhancement of antioxidant pathways.

METHODS: Transcriptome analysis, PCR and ELISA were undertaken to delineate markers of inflammation and oxidative stress; with comparison of expression in primary HBECs from healthy and asthmatic donors cultured with reference urban PM in the presence/absence of vitamin D.

RESULTS:
Transcriptome analysis identified over 500 genes significantly perturbed by PM-stimulation, including multiple pro-inflammatory cytokines. Vitamin D altered expression of a subset of these PM-induced genes, including suppressing IL6. Addition of vitamin D suppressed PM-stimulated IL-6 production, although to significantly greater extent in healthy versus asthmatic donor cultures. Vitamin D also differentially affected PM-stimulated GM-CSF, with suppression in healthy HBECs and enhancement in asthmatic cultures. Vitamin D increased HBEC expression of the antioxidant pathway gene G6PD, increased the ratio of reduced to oxidised glutathione, and in PM-stimulated cultures decreased the formation of 8-isoprostane. Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect abrogated by inhibition of G6PD with DHEA, supporting a role for this pathway in the anti-inflammatory actions of vitamin D.

CONCLUSIONS:
In a study using HBECs from 18 donors, vitamin D enhanced HBEC antioxidant responses and modulated the immune response to PM, suggesting that vitamin D may protect the airways from pathological pollution-induced inflammation.

 Download the PDF from VitaminDWiki


Note: Particulate matter problems apparently treated by inhaling Vitamin D

By the founder of VitaminDWiki, who lives near Seattle
In Aug of 2018 there was a lot of particulate matter in the air
The air pollution from wildfires has recently been called a smokestorm (by Cliff Mass)
I went for a bike ride when the smokestorm was almost gone
Felt a restriction in my breathing that night and the next morning.,
I inhaled 3 puffs of Vitamin D and the restriction totally went away in less than an hour
I do not know if the Vitamin D treated the health problem or it the problem would have gone away without it.
   Henry Lahore


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Air Pollution reduces Vitamin D        

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Attached files

ID Name Comment Uploaded Size Downloads
10437 particulate matter.pdf PDF 2018 admin 30 Aug, 2018 11:57 4.37 Mb 63
8029 Low serum vitamin D-status, air pollution and obesity.pdf PDF 2016 admin 28 May, 2017 14:25 513.62 Kb 498
3673 Pollution and factory efficiency.pdf PDF 2014 admin 05 Mar, 2014 22:43 691.33 Kb 1618
3586 UVB decrease due to pollution.jpg admin 26 Jan, 2014 13:21 31.87 Kb 3849
3585 UVB and pollution-2008.pdf PDF admin 26 Jan, 2014 13:20 7.11 Mb 2308
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