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Acute Lower Respiratory Infections in Children - associated with low vitamin D – meta-analysis Dec 2014

Vitamin D Deficiency and Acute Lower Respiratory Infections in Children Younger Than 5 Years: Identification and Treatment

Journal of Pediatric Health Care, Volume 28, Issue 6, November–December 2014, Pages 572–582
Allison Larkin, MS, NP-C, , Jane Lassetter, PhD, RN

Acute lower respiratory infection (ALRI) is a leading cause of childhood mortality. Research suggests that vitamin D deficiency (VDD) puts children at risk for ALRI. The purpose of this review is to examine ALRI and VDD in children 5 years and younger. Common etiologies, diagnosis, prevention, treatment of ALRI, and recommendations for vitamin D supplementation are summarized.

Databases were searched for studies investigating VDD and ALRI in children. Independent reviewers assessed the internal validity of the studies.

Of 18 studies examined, VDD was found to be associated with increased risk or severity of ALRI in 13 studies; associations were not found in 4 studies. In one study it was found that high maternal vitamin D levels was associated with ALRI in infants.

Vitamin D supplementation is a low-cost, low-risk intervention that providers should consider for children, especially those at high risk for ALRI. Practitioners should follow current recommendations when prescribing vitamin D supplementation for infants and children.

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