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COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020

Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study

European Journal of Nutrition https://doi.org/10.1007/s00394-020-02411-0



73 patients in Iran in Spring
Note: 5-month delay from when the report was received to when it was published

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Vitamin D deficiency has been reported as a key factor in the development of infectious diseases such as respiratory tract infections and inflammatory processes like acute respiratory distress syndrome. However, the impact of vitamin D on the severity and outcome of COVID-19 is still not fully known. Herein, we aimed to evaluate the prognostic role of serum vitamin D concentration on the extent of lung involvement and final outcome in patients with COVID-19.

Seventy-three subjects with confirmed diagnosis of COVID-19 were investigated in this study. The patients had been admitted to our academic hospital from February 28, 2020 to April 19, 2020. Demographic and clinical data, serum 25(OH)D levels, and findings of initial chest computed tomography were recorded. Linear and binary logistic regression, cox regression and ROC curve tests were used for statistical analysis.

The mean age of patients was 55.18 ± 14.98 years old; 46.4% were male. Mean serum 25(OH)D concentration was significantly lower in the deceased (13.83 ± 12.53 ng/ mL compared with discharged patients (38.41 ± 18.51 ng/mL) (P < 0.001). Higher levels of 25(OH)D were associated with significantly less extent of total lung involvement (β = − 0.10, P = 0.004). In addition, vitamin D deficiency [25(OH) D < 25 ng/mL] was associated with a significant increase in the risk of mortality (hazard ratio = 4.15, P = 0.04).

This study suggests that serum vitamin D status might provide useful information regarding the clinical course, extent of lung involvement and outcome of patients with COVID-19. However, further studies with larger sample size are needed to confirm these findings.

Created by admin. Last Modification: Sunday January 10, 2021 04:29:13 GMT-0000 by admin. (Version 12)

Attached files

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14502 Model.jpg admin 30 Oct, 2020 104.31 Kb 750
14501 Baseline variables.jpg admin 30 Oct, 2020 70.64 Kb 711
14500 Low D4 X more likely to die of COVID-19 - Oct 30.pdf admin 30 Oct, 2020 1.09 Mb 421