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Small doses of vitamin D do not reduce risk of Acute Respiratory Infection - meta-analysis Feb 2022


Efficacy of Vitamin D Supplements in Prevention of Acute Respiratory Infection: A Meta-Analysis for Randomized Controlled Trials

Nutrients 2022, 14(4), 818; https://doi.org/10.3390/nu14040818 (registering DOI)
by Hae-Eun Cho 1,Seung-Kwon Myung 2,3,4,* and Herim Cho 1

Background: Previous systematic reviews and meta-analyses of randomized controlled trials (RCTs) have reported inconsistent results regarding the efficacy of vitamin D supplements in the prevention of acute respiratory infections (ARIs).

Methods: We investigated these efficacy results by using a meta-analysis of RCTs. We searched PubMed, EMBASE, and the Cochrane Library in June 2021.

Results: Out of 390 trials searched from the database, a total of 30 RCTs involving 30,263 participants were included in the final analysis. In the meta-analysis of all the trials, vitamin D supplementation showed no significant effect in the prevention of ARIs (relative risk (RR) 0.96, 95% confidence interval (CI) 0.91–1.01, I2 = 59.0%, n = 30). In the subgroup meta-analysis, vitamin D supplementation was effective in daily supplementation (RR 0.83, 95% CI, 0.73–0.95, I2 = 69.1%, n = 15) and short-term supplementation (RR 0.83, 95% CI, 0.71–0.97, I2 = 66.8%, n = 13). However, such beneficial effects disappeared in the subgroup meta-analysis of high-quality studies (RR 0.89, 95% CI, 0.78–1.02, I2 = 67.0%, n = 10 assessed by the Jadad scale; RR 0.87, 95% CI, 0.66–1.15, I2 = 51.0%, n = 4 assessed by the Cochrane’s risk of bias tool). Additionally, publication bias was observed.

Conclusions: The current meta-analysis found that vitamin D supplementation has no clinical effect in the prevention of ARIs.
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Title Modified
Small doses of vitamin D do not reduce risk of Acute Respiratory Infection - meta-analysis Feb 2022 15 Feb, 2022
Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020 24 Sep, 2021
Small vitamin D doses provide small benefits for acute respiratory infections – Meta-analysis March 2021 31 Mar, 2021
Acute pneumonia in children 3X less likely if greater than 30 ng of vitamin D – Jan 2021 20 Mar, 2021
Acute respiratory tract infections not reduced by Vitamin D if already have a good level – Jan 2020 15 Jan, 2021
Acute respiratory distress – 100 percent of patients were vitamin D deficient– April 2015 09 Jun, 2019
Acute respiratory tract infections prevented by vitamin D (even when ignoring the dose size – Meta-analysis Feb 2017 09 Aug, 2017
Acute Lower Respiratory Infections in Children - associated with low vitamin D – meta-analysis Dec 2014 16 Sep, 2016
Acute respiratory infection treated by vitamin D in 6 of 12 clinical trials – review Nov 2012 15 May, 2016
Acute respiratory infection worsened by too infrequent vitamin D supplementation – RCT June 2015 17 Dec, 2015
Common cold (Acute Rhinosinusitis) 12 percent more likely for every 10 nanogram lower Vitamin D – Oct 2015 13 Oct, 2015
Low dose Vitamin D during pregnancy and infancy results in strange acute respiratory infection response – April 2015 24 Mar, 2015
Acute lower respiratory infection 5X more frequent with low vitamin D intake – June 2012 20 Mar, 2015
Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015 20 Mar, 2015
100 percent of Acute Respiratory Failure patients had low vitamin D - April 2012 21 Jun, 2013

Created by admin. Last Modification: Saturday February 26, 2022 18:08:52 GMT-0000 by admin. (Version 3)

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17056 Acute Respiratory Infection Meta.pdf PDF 2022 admin 15 Feb, 2022 17:27 1.04 Mb 44
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