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Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019

The relation between serum vitamin D levels, viral infections and severity of attacks in children with recurrent wheezing

Allergologia et Immunopathologia, Vol 47, Issue 6, Nov–Dec 2019, Pages 591-597, https://doi.org/10.1016/j.aller.2019.05.002

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Introduction and Objectives
Vitamin D deficiency is associated with increased susceptibility to infections and wheezing. We aimed to evaluate the relation between vitamin D levels, viral infections and severity of attacks in children with recurrent wheezing.

Materials and methods
A total of 52 patients who applied with wheezing, at the ages of 12–60 months with a history of three or more wheezing attacks in the last year and 54 healthy children were included. Sociodemographic data, risk factors for recurrent wheezing, and the severity of the wheezing attacks were recorded. 25(OH)D3, calcium, phosphor, alkaline phosphatase and parathormone levels of all children were measured. Nasopharyngeal samples of the patients for viruses were studied by multiplex polymerase chain reaction.

For the patient group, being breastfed for six months or less, history of cesarean section, cigarette exposure, humid home environment, and family history of allergic disease were significantly higher compared with the control group. Serum vitamin D levels in the patient group were significantly lower compared to the control group. There was no significant relationship between vitamin D levels and hospitalization, oxygen or steroid therapy. Virus was detected in 38 patients (73%). Rhinovirus (63.2%) was the most frequently detected virus. Coinfection was found in 14 (36.8%) patients. There was no statistically significant difference between detection of virus and vitamin D levels.

Cigarette exposure, being breastfed six months or less, humid home environment, history of cesarean section, family history of allergic disease and vitamin D deficiency might be risk factors for recurrent wheezing.

Clipped from PDF

A serum 25(OH)D3 level of >20 ng/mL is indicative of vitamin D sufficiency,
a level of 15- - 20 ng/mL as vitamin D insufficiency,
a level of <15 ng/mL as vitamin D deficiency,
and a level of ≤5 ng/mL as severe deficiency for children.1

Each sample was simultaneously tested for human adenovirus (HAdV), influenza viruses A, B and H1N1 (FluA, FluB, H1N1), human coronaviruses (HCoV-229E, HCoV-HKU, HCoV-NL63, HCoV-OC43), human metapneumovirus (HMPV), human parainfluenza viruses (HPIV-1, HPIV-2, HPIV-3 and HPIV-4), human respiratory sinsitial virus (HRSV A/B), human enterovirus (HEV) and rhinovirus (RV).

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Items found: 15
Title Modified
Vitamin D levels are low during Recurrent Wheezing - Feb 2024 24 Feb, 2024
Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 21 Dec, 2023
Recurrent Wheezing in children is associated with low Vitamin D – several studies 04 Sep, 2022
Wheezing and asthmatic children have weaker Vitamin D responses - May 2022 19 May, 2022
Vitamin D reduces RTI, Omega-3 reduces wheezing or asthma – March 2022 11 Apr, 2022
Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019 04 Apr, 2020
Gene which predicts wheezing is associated with low vitamin D – Oct 2019 18 Oct, 2019
Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018 06 Dec, 2018
Recurrent wheeze 2X more likely if endotoxin (on some bacteria) and low vitamin D – May 2016 15 Dec, 2017
Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015 10 May, 2016
2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 09 Sep, 2015
Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015 25 Aug, 2015
Children who wheezed were 2.7X more likely to have little vitamin D – April 2014 18 Apr, 2015
Vitamin D and wheeze – especially in seniors – Aug 2011 26 Apr, 2014
Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013 30 Jun, 2013

Created by admin. Last Modification: Saturday February 24, 2024 22:54:31 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
13707 Wheeze table 6.jpg admin 04 Apr, 2020 39.41 Kb 560
13706 Wheezing tabke 4.jpg admin 04 Apr, 2020 57.76 Kb 560
13705 Viral Infections wheezing.pdf admin 04 Apr, 2020 299.64 Kb 486