The relation between serum vitamin D levels, viral infections and severity of attacks in children with recurrent wheezing
Allergologia et Immunopathologia, Vol 47, Issue 6, Nov–Dec 2019, Pages 591-597, https://doi.org/10.1016/j.aller.2019.05.002
Items in both categories Breathing and Virus are listed here:
- Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
- Calcifediol (semi-activated Vitamin D) might treat Respiratory Diseases such as COVID - July 2022
- Croup (due to viruses) has surged with Omicron - March 2022
- Compare symptoms of Omicron, Flu and Colds
- Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis Jan 2022
- Italians entering hospital for breathing problems had low vitamin D (with and without COVID), Vitamin D should help – Nov 2021
- Superspreaders appear to have viscous lung fluids or be obese
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020
- COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020
- Respiratory viral infection (RSV) and low vitamin D - many studies
- Zinc, respiratory tract infections and COVID-19 – July 2020
- Vitamin D reduces viral respiratory infections – editorial April 18, 2020
- Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019
- Ultraviolet light kills cold and flu viruses, and generates Vitamin D in the skin
- Respiratory Virus risk reduced 35 percent by Vitamin D (14,000 IU weekly) – RCT Oct 2018
- Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Loss of smell may be related to low Zinc or perhaps low vitamin D
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Immune response to respiratory viruses – vitamin D connection – review May 2015
- Overview Colds and flu and Vitamin D
- Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010
Breathing category starts with the following
Introduction and Objectives
Vitamin D deficiency is associated with increased susceptibility to infections and wheezing. We aimed to evaluate the relation between vitamin D levels, viral infections and severity of attacks in children with recurrent wheezing.
Materials and methods
A total of 52 patients who applied with wheezing, at the ages of 12–60 months with a history of three or more wheezing attacks in the last year and 54 healthy children were included. Sociodemographic data, risk factors for recurrent wheezing, and the severity of the wheezing attacks were recorded. 25(OH)D3, calcium, phosphor, alkaline phosphatase and parathormone levels of all children were measured. Nasopharyngeal samples of the patients for viruses were studied by multiplex polymerase chain reaction.
For the patient group, being breastfed for six months or less, history of cesarean section, cigarette exposure, humid home environment, and family history of allergic disease were significantly higher compared with the control group. Serum vitamin D levels in the patient group were significantly lower compared to the control group. There was no significant relationship between vitamin D levels and hospitalization, oxygen or steroid therapy. Virus was detected in 38 patients (73%). Rhinovirus (63.2%) was the most frequently detected virus. Coinfection was found in 14 (36.8%) patients. There was no statistically significant difference between detection of virus and vitamin D levels.
Cigarette exposure, being breastfed six months or less, humid home environment, history of cesarean section, family history of allergic disease and vitamin D deficiency might be risk factors for recurrent wheezing.
A serum 25(OH)D3 level of >20 ng/mL is indicative of vitamin D sufficiency,
a level of 15--20 ng/mL as vitamin D insufficiency,
a level of <15 ng/mL as vitamin D deficiency,
and a level of ≤5 ng/mL as severe deficiency for children.1
Each sample was simultaneously tested for human adenovirus (HAdV), influenza viruses A, B and H1N1 (FluA, FluB, H1N1), human coronaviruses (HCoV-229E, HCoV-HKU, HCoV-NL63, HCoV-OC43), human metapneumovirus (HMPV), human parainfluenza viruses (HPIV-1, HPIV-2, HPIV-3 and HPIV-4), human respiratory sinsitial virus (HRSV A/B), human enterovirus (HEV) and rhinovirus (RV).
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