Pain relieved by Vitamin D if trial lasted more than 5 months (endometriosis, 50K weekly for 12 months) – Aug 2023

Another endometriosis-related pain trial lasting only 3 months did not result in a benefit.
It takes at least 5 months for vitamin D dosing to fully respond without a loading dose
Loading doses, on the other hand, result in a response/benefit in < 1 month

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Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis

Reproductive Biology and Endocrinology Vol 21, # 79 (2023) https://doi.org/10.1186/s12958-023-01126-1
Sai-Hua Zheng, Xiu-Xia Chen, Yi Chen, Zhi-Cong Wu, Xian-Qian Chen & Xue-Lian Li

Objective
This study aimed to clarify the effect of antioxidant vitamins supplementation on endometriosis-related pain.

Methods
A systematic search of PubMed, Web of Science, Cochrane Library, Scopus, and China National Knowledge Infrastructure (CNK) databases was conducted to identify relevant studies published in English and Chinese up to 16 March 2023. The search terms used were "endometriosis" OR "endometrioma" OR "endometrium" AND "antioxidant" OR "Vitamin C" OR "Vitamin E" OR "Vitamin D" OR "25-OHD" OR "25(OH)D" OR "25-hydroxyvitamin D". Eligible studies were randomized controlled trials (RCTs) that assessed pain scores using the Visual Analogue Scale (VAS). Mean differences or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the effect of antioxidant vitamins supplementation on endometriosis. The quality of the included studies was assessed using the Cochrane Risk of Bias Tool. The study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines.

Results
A total of 13 RCTs involving 589 patients were included in this meta-analysis. We identified 11 studies that evaluated the effect of antioxidant vitamins supplementation on endometriosis-related pain. The results indicated that the supplementation of antioxidant vitamins can effectively alleviate endometriosis-related pain. Subgroup analysis showed that the supplementation of vitamin E (with or without vitamin C) had a positive effect on improving clinical pelvic pain in patients with chronic pelvic pain. Conversely, supplementation of vitamin D was associated with a reduction in pelvic pain in endometriosis patients, but the difference was not statistically significant compared to the placebo. Additionally, we observed changes in oxidative stress markers following vitamin supplementation. Plasma malondialdehyde (MDA) concentration decreased in patients with endometriosis after antioxidant vitamin supplementation, and the plasma MDA level was inversely correlated with the time and dose of vitamin E and C supplementation. Furthermore, the inflammatory markers in peritoneal fluid, including RANTES, interleukin-6, and monocyte chemoattractant protein-1, significantly decreased after antioxidant therapy. These findings suggest that antioxidant vitamins may alleviate pain in endometriosis patients by reducing inflammation.

Conclusions
The included studies support the potential role of antioxidant vitamins in the management of endometriosis. Supplementation with antioxidant vitamins effectively reduced the severity of dysmenorrhea, improved dyspareunia and pelvic pain, and enhanced quality of life in these patients. Therefore, antioxidant vitamin therapy could be considered as an alternative treatment method, either alone or in combination with other approaches, for endometriosis-related pain.
 Download the PDF from VitaminDWiki

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From study - dysmenorrhea pain reduced by 50,000 IU weekly or bi-weekly for 12 months

• Risk of dysmenorrhea reduced 3.02 (page 4)
• "While one study by Almassinokiani et al. found that a 12-week supplementation of 50,000 IU vitamin D after ablative surgery for endometriosis did not signifcantly impact dysmenorrhea (p= 0.45) and pelvic pain (p= 0.24) [23],"

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VitaminDWiki – Pain - chronic category contains:

167 items in category Chronic pain

See also

• Overview Pain and Vitamin D
• Percentage of people with pain increased 25 percent in 18 years – Jan 2019
• Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
• Overview Fibromyalgia or Chronic Fatigue and vitamin D
• Overview Rheumatoid Arthritis and vitamin D
• Shingles and vitamin D
• Shin splints decrease with vitamin D
• Migraine and Vitamin D
• Headache category 82 items
• "musculoskeletal pain" 490 items as of Aug 2023
• "chronic fatigue" 185 items as of Jan 2017
• Category Back Pain 44 items
• 7 pain studies in VitaminDWiki with KNEE in the title as of Aug 2023 (see below)
• Opioid OR Opiate OR Morphine in the title 10 pages as of June 2021

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VitaminDWiki – Loading Dose of Vitamin D category contains:

206 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has 64 items
 
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading doses

TOP articles in Loading Dose of Vitamin D

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VitaminDWiki - 8 studies in both categories Pain and Loading Dose

This list is automatically updated

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See also in VitaminDWiki - Endometriosis treated, and perhaps prevented, by vitamin D - many studies

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Example: Endometriosis treated by Vitamin D (50,000 IU bi-weekly) – RCT Jan 2021