Another endometriosis-related pain trial lasting only 3 months did not result in a benefit.
It takes at least 5 months for vitamin D dosing to fully respond without a loading dose
Loading doses, on the other hand, result in a response/benefit in < 1 month
- Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis
- VitaminDWiki – Pain - chronic category contains:
- VitaminDWiki – Loading Dose of Vitamin D category contains:
- TOP articles in Loading Dose of Vitamin D
- VitaminDWiki -
8 studies in both categories Pain and Loading Dose - See also in VitaminDWiki - Endometriosis treated, and perhaps prevented, by vitamin D - many studies
Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis
Reproductive Biology and Endocrinology Vol 21, # 79 (2023) https://doi.org/10.1186/s12958-023-01126-1
Sai-Hua Zheng, Xiu-Xia Chen, Yi Chen, Zhi-Cong Wu, Xian-Qian Chen & Xue-Lian LiObjective
This study aimed to clarify the effect of antioxidant vitamins supplementation on endometriosis-related pain.Methods
A systematic search of PubMed, Web of Science, Cochrane Library, Scopus, and China National Knowledge Infrastructure (CNK) databases was conducted to identify relevant studies published in English and Chinese up to 16 March 2023. The search terms used were "endometriosis" OR "endometrioma" OR "endometrium" AND "antioxidant" OR "Vitamin C" OR "Vitamin E" OR "Vitamin D" OR "25-OHD" OR "25(OH)D" OR "25-hydroxyvitamin D". Eligible studies were randomized controlled trials (RCTs) that assessed pain scores using the Visual Analogue Scale (VAS). Mean differences or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the effect of antioxidant vitamins supplementation on endometriosis. The quality of the included studies was assessed using the Cochrane Risk of Bias Tool. The study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines.Results
A total of 13 RCTs involving 589 patients were included in this meta-analysis. We identified 11 studies that evaluated the effect of antioxidant vitamins supplementation on endometriosis-related pain. The results indicated that the supplementation of antioxidant vitamins can effectively alleviate endometriosis-related pain. Subgroup analysis showed that the supplementation of vitamin E (with or without vitamin C) had a positive effect on improving clinical pelvic pain in patients with chronic pelvic pain. Conversely, supplementation of vitamin D was associated with a reduction in pelvic pain in endometriosis patients, but the difference was not statistically significant compared to the placebo. Additionally, we observed changes in oxidative stress markers following vitamin supplementation. Plasma malondialdehyde (MDA) concentration decreased in patients with endometriosis after antioxidant vitamin supplementation, and the plasma MDA level was inversely correlated with the time and dose of vitamin E and C supplementation. Furthermore, the inflammatory markers in peritoneal fluid, including RANTES, interleukin-6, and monocyte chemoattractant protein-1, significantly decreased after antioxidant therapy. These findings suggest that antioxidant vitamins may alleviate pain in endometriosis patients by reducing inflammation.Conclusions
The included studies support the potential role of antioxidant vitamins in the management of endometriosis. Supplementation with antioxidant vitamins effectively reduced the severity of dysmenorrhea, improved dyspareunia and pelvic pain, and enhanced quality of life in these patients. Therefore, antioxidant vitamin therapy could be considered as an alternative treatment method, either alone or in combination with other approaches, for endometriosis-related pain.
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From study - dysmenorrhea pain reduced by 50,000 IU weekly or bi-weekly for 12 months
- Risk of dysmenorrhea reduced 3.02 (page 4)
- "While one study by Almassinokiani et al. found that a 12-week supplementation of 50,000 IU vitamin D after ablative surgery for endometriosis did not signifcantly impact dysmenorrhea (p= 0.45) and pelvic pain (p= 0.24) [23],"
VitaminDWiki – Pain - chronic category contains:
167 items in category Chronic pain See also
- Overview Pain and Vitamin D
- Percentage of people with pain increased 25 percent in 18 years – Jan 2019
- Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
- Overview Fibromyalgia or Chronic Fatigue and vitamin D
- Overview Rheumatoid Arthritis and vitamin D
- Shingles and vitamin D
- Shin splints decrease with vitamin D
- Migraine and Vitamin D
- Headache category
82 items - "musculoskeletal pain" 490 items as of Aug 2023
- "chronic fatigue" 240 items have it in title or abstract as of Dec 2024
- Category Back Pain
44 items - 7 pain studies in VitaminDWiki with KNEE in the title as of Aug 2023 (see below)
- Opioid OR Opiate OR Morphine in the title 10 pages as of June 2021
VitaminDWiki – Loading Dose of Vitamin D category contains:
207 items in category
see also Overview Loading of vitamin D Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has65 items
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading dosesTOP articles in Loading Dose of Vitamin D
- Vitamin D loading dose of 30,000 IU twice a week is safe and effective – RCT July 2023
- Large dose Vitamin D before surgery was found to help by 35 studies
- Vitamin D is needed before most surgeries – many studies and RCTs
- 400,000 IU of vitamin D 3 days after COVID symptoms reduced 14 day mortality by 3X – Annweiler RCT May 2022
- High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022
- Take lots of Vitamin D at first signs of COVID
- Rapid Vitamin D Delivery May Result in Better COVID Outcomes - Dec 9, 2021
- Vitamin D loading doses quickly and safely raise levels – meta-analysis Dec 2021
- Childhood cancers – give Vitamin D loading dose if low – Oct 2021
- French recommended 200,000 IU of Vitamin D to stop COVID-19 - Jan 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- Vitamin D loading dose (stoss therapy) proven to improve health
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018
- Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT Nov 2018
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Reasons for Low Vitamin D and what to do
- Healthy in Seven Days - Loading dose of Vitamin D – book 2014
- Can get 50,000 IU Vitamin D anywhere on the globe
VitaminDWiki -
8 studies in both categories Pain and Loading Dose This list is automatically updated
- Growing pains reduced in 91% of children with a single dose of Vitamin D – July 2024
- Pain relieved by Vitamin D if trial lasted more than 5 months (endometriosis, 50K weekly for 12 months) – Aug 2023
- Large dose Vitamin D before surgery was found to help by 35 studies
- 3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020
- Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020
- Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016
- 400,000 IU of vitamin D reduced adult pain and improved quality of life – March 2014
- Vitamin D injections of a total of 1,800,000 IU reduced shinbone tenderness – Feb 2013
See also in VitaminDWiki - Endometriosis treated, and perhaps prevented, by vitamin D - many studies
Example: Endometriosis treated by Vitamin D (50,000 IU bi-weekly) – RCT Jan 2021
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