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Obesity not helped by daily vitamin D (summary of 20 RCTs using 100 IU to 8,000 IU) – July 2020

Effects of Vitamin D Supplementation on General and Central Obesity: Results From 20 Randomized Controlled Trials Involving Apparently Healthy Populations

Ann Nutr Metab. 2020 Jul 9;1-12. doi: 10.1159/000507418.
Leizhen Duan 1, Ling Han 1, Qin Liu 1, Yili Zhao 1, Lei Wang 1, Yan Wang 2

VitaminDWiki

It is amazing how many review studies ignor amount of Vitamin D given

Overview Obesity and Vitamin D contains the following summary

Obese need more Vitamin D
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  • Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study

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  • Normal weight     Obese     (50 ng = 125 nanomole)


Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has the following
Fast weight loss by Obese Adults: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
   If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
   * Vitamin D levels must be above 30ng/ml to help with weight loss
   * Start losing weight 2 months sooner if take a 50,000 IU daily for a week
3) More weight loss if also add Magnesium or cofactors
   30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
   Note: Magnesium reduces weight loss by itself as well
   20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
  Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
   Vitamin D Receptor activator: 0-30% improved Vitamin D response
   Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
Update Dec 2019 - Dr. Greger plant-based eating (not diet) for both weight loss and health.
  His book does not mention Vitamin D nor Adenovirus

Items in both categories Obesity and Intervention are listed here:

 Download the PDF from VitaminDWiki
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Background: The obesity pandemic has been paralleled by a high prevalence of vitamin D deficiency (VDD). There is growing epidemiological evidence linking low vitamin D status with obesity events. In addition, observational studies also show that obesity may increase the risk of VDD. However, there is insufficient knowledge to understand whether there is a causality between the two. Moreover, the impact of vitamin D supplementation on obesity indices has shown inconsistent outcomes.

Objective: This meta-analysis aimed to assess whether vitamin D supplementation modified general and central obesity indices in apparently healthy populations.

Methods: A systematic retrieval of relevant randomized controlled trials (RCTs) was undertaken using Pubmed, Embase, Web of Knowledge and Chinese National Knowledge Infrastructure databases. The pooled weighted mean difference (WMD) and 95% confidence intervals (CI) were used to assess the changes in body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and 25-hydroxyvitamin D (25OHD) from baseline.

Results: Twenty RCTs involving 3,153 participants reporting either BMI, WC, WHR or 25(OH)D met the inclusion criteria. When compared with placebo, vitamin D supplementation had no significant decreases in BMI (WMD = -0.09 kg/m2, 95% CI -0.19 to 0.01, p = 0.08), WC (WMD = -0.71 cm, 95% CI -1.58 to 0.16, p = 0.112) or WHR (WMD = 0.00, 95% CI -0.01 to 0.01, p = 0.749). However, in the subgroups of females, Asia region studies and intervention duration ≥6 months, a beneficial and significant reduction in BMI and WC was noted (all p < 0.026). On the other hand, pooled results showed that there was a significant increase in serum 25(OH)D levels (WMD = 13.20 ng/mL, 95% CI 9.83-16.58, p < 0.001) after vitamin D intervention. No publication bias was found in our study.

Conclusions: Overall, supplementation with vitamin D produced no significant effect on the BMI, WC or WHR of healthy adults.


Created by admin. Last Modification: Friday July 10, 2020 13:52:59 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
14017 Obesity IU.jpg admin 10 Jul, 2020 74.55 Kb 324
14016 20 RCT Obesity.pdf admin 10 Jul, 2020 477.12 Kb 453