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Obesity not helped by daily vitamin D (summary of 20 RCTs using 100 IU to 8,000 IU) – July 2020

Effects of Vitamin D Supplementation on General and Central Obesity: Results From 20 Randomized Controlled Trials Involving Apparently Healthy Populations

Ann Nutr Metab. 2020 Jul 9;1-12. doi: 10.1159/000507418.
Leizhen Duan 1, Ling Han 1, Qin Liu 1, Yili Zhao 1, Lei Wang 1, Yan Wang 2


It is amazing how many review studies ignor amount of Vitamin D given

Overview Obesity and Vitamin D contains the following summary


  • Normal weight     Obese     (50 ng = 125 nanomole)

Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has the following
Fast weight loss by Obese: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
   If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
   * Vitamin D levels must be above 30ng/ml to help with weight loss
   * Start losing weight 2 months sooner if take a 50,000 IU daily for a week
3) More weight loss if also add Magnesium or cofactors
   30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
   Note: Magnesium reduces weight loss by itself as well
   20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
  Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
   Vitamin D Receptor activator: 0-30% improved Vitamin D response
   Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
Update Dec 2019 - Dr. Greger plant-based eating (not diet) for both weight loss and health.
  His book does not mention Vitamin D nor Adenovirus

Items in both categories Obesity and Intervention are listed here:

 Download the PDF from VitaminDWiki

Background: The obesity pandemic has been paralleled by a high prevalence of vitamin D deficiency (VDD). There is growing epidemiological evidence linking low vitamin D status with obesity events. In addition, observational studies also show that obesity may increase the risk of VDD. However, there is insufficient knowledge to understand whether there is a causality between the two. Moreover, the impact of vitamin D supplementation on obesity indices has shown inconsistent outcomes.

Objective: This meta-analysis aimed to assess whether vitamin D supplementation modified general and central obesity indices in apparently healthy populations.

Methods: A systematic retrieval of relevant randomized controlled trials (RCTs) was undertaken using Pubmed, Embase, Web of Knowledge and Chinese National Knowledge Infrastructure databases. The pooled weighted mean difference (WMD) and 95% confidence intervals (CI) were used to assess the changes in body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and 25-hydroxyvitamin D (25OHD) from baseline.

Results: Twenty RCTs involving 3,153 participants reporting either BMI, WC, WHR or 25(OH)D met the inclusion criteria. When compared with placebo, vitamin D supplementation had no significant decreases in BMI (WMD = -0.09 kg/m2, 95% CI -0.19 to 0.01, p = 0.08), WC (WMD = -0.71 cm, 95% CI -1.58 to 0.16, p = 0.112) or WHR (WMD = 0.00, 95% CI -0.01 to 0.01, p = 0.749). However, in the subgroups of females, Asia region studies and intervention duration ≥6 months, a beneficial and significant reduction in BMI and WC was noted (all p < 0.026). On the other hand, pooled results showed that there was a significant increase in serum 25(OH)D levels (WMD = 13.20 ng/mL, 95% CI 9.83-16.58, p < 0.001) after vitamin D intervention. No publication bias was found in our study.

Conclusions: Overall, supplementation with vitamin D produced no significant effect on the BMI, WC or WHR of healthy adults.

Created by admin. Last Modification: Friday July 10, 2020 13:52:59 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
14017 Obesity IU.jpg admin 10 Jul, 2020 13:48 74.55 Kb 106
14016 20 RCT Obesity.pdf PDF 2020 admin 10 Jul, 2020 13:47 477.12 Kb 109
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