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Daily, monthly Vitamin D had similar great benefits, more than 6 months needed – RCT Dec 2018

Vitamin D Daily versus Monthly Administration: Bone Turnover and Adipose Tissue Influences

Nutrients 2018, 10(12), 1934; https://doi.org/10.3390/nu10121934 Published: 6 Dec 2018


1750 IU)/day vs. 50,000 IU/month
Results of 50,000 IU/month
Vitamin D @ 0 months = 21 ng
Vitamin D @ 6 months = 36 ng
Vitamin D @ 18 months = 41 ng
Note: Many studies feel that vitamin D plateaus in 2-3 months, this study needed 6+ months

Weekly, biweekly, and sometimes even monthly dosing better than daily

  • Bodies have been evolved to store vitamin D (not require daily sunshine)
  • Many studies have found non-daily dosing of Vitamin D to actually produce better results than daily
  • Intermittent (<19 days) appears to provide the most benefit, but monthly dosing is OK (~30ng)
  • Take vitamin D3 daily or weekly
    Hypothesis: Concentration Gradient pushes more vitamin D across barriers

Notion of Vitamin D benefit vs dosing frequency for ~30 nanograms
see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=2475

Notion of Vitamin D benefit vs dosing frequency for > 50 nanograms
see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=2475

 Download the PDF from VitaminDWiki

Luca Dalle Carbonare 1,2, Maria Teresa Valenti 1,2,* , Francesco del Forno 1,2, Giorgio Piacentini 3 and Angelo Pietrobelli 3,4
1 Clinic of Internal Medicine, Section D, Department of Medic89e, University of Verona, 37134 Verona, Italy
2 Specialized Regional Center for Biomolecular and Histomorphometric Research for Skeletal and Degenerative Diseases, 37134 Verona, Italy
3 Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, 37134 Verona, Italy
4 Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA

Vitamin D is involved in bone metabolism and in many various extra-skeletal diseases such as malabsorption syndromes, cardiovascular and metabolic diseases, cancer, and autoimmune and neurological diseases. However, data on the optimal route of administration are not consistent. The aims of our study were to analyze not only the influence of daily vs. monthly administration of vitamin D on bone metabolism and bone turnover, but also the effects of different routes of administration on fat mass in a cohort of adults with low levels of 25(OH) vitamin D3 at baseline. We analyzed 44 patients with hypovitaminosis at baseline and after six months of two different regimens of administration: seven drops (1750 IU)/day vs. 50,000 IU/month. We found that the two regimens were equivalent; 36 out of 44 patients reached the normal range of vitamin D after six months of treatment. Interestingly, the main determinant of vitamin D at baseline was the waist circumference.
In addition, 22 patients treated by monthly regimen were evaluated after 18 months of treatment. At the end of follow-up, patients showed normal levels of vitamin D, with increased calcium levels and decreased bone turnover. Waist circumference also decreased. Our results support the efficacy of vitamin D3 given monthly both for correcting hypovitaminosis and for maintaining vitamin D levels. The relationship between serum 25(OH)vitamin D3 concentration and waist circumference supports vitamin D having a protective role in the current setting, since waist size is directly associated with the risk of cardiovascular and metabolic diseases

Created by admin. Last Modification: Thursday December 6, 2018 16:30:19 GMT-0000 by admin. (Version 12)

Attached files

ID Name Comment Uploaded Size Downloads
10989 Daily, monthly.pdf PDF 2018 admin 06 Dec, 2018 11:24 1.05 Mb 8
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