J. of Clinical & Translational Endocrinology, Vol 12, June 2018, Pages 1-7. https://doi.org/10.1016/j.jcte.2018.03.001
Sheela N.Maggeb1 Divya Prasada Babette S.Zemelc Andrea Kellya
Items in both categories Obesity and Dark Skin are listed here:
- Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily – June 2018
- Stroke outcome 6.9 X worse if black and overweight (all three related via low vitamin D) – March 2018
- Indoor pollution is a problem with obese black asthmatic children – May 2018
- Blacks are more obese, have lower Vitamin D, and have more Cancer etc. than whites – Feb 2018
- Increase in Vitamin D deficiency with weight and skin darkness – chart – March 2016
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015
- Obese diabetics with dark skins not benefit from 6,000 IU of vitamin D daily (no surprise) – RCT March 2015
- African-Americans at high risk of obesity and diabetes - 2011
- Bariatric surgery less than 30 ng of vitamin D – 82 pcnt teens, 100 pcnt of black teens – June 2012
- Low vitamin D associated with obesity-related diseases for ethnic minorities – Sept 2011
- Reasons for low response to vitamin D
- Telomeres improved when obese blacks took 2000 IU of vitamin D daily – Oct 2011
- Black women lacking Calcium and Vitamin D weighed more – Aug 2011
- Dark skinned obese not helped much by weekly 50000 IU dose of vitamin D – May 2011
- Obese children had low vitamin D – fat under dark skin – fat in white body – Mar 2011
- Obesity in American-Indians and African-American teens
- Vitamin D3 in obese and non obese African American children – 2008
- Low vitamin D in teens: especially black or overweight – June 2010
Overview Obesity and Vitamin D contains the following summary__
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 126 trials for vitamin D intervention of obesity as of Dec 2017
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Those with darker skins were more likely to be obese Sept 2014
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
- Obesity category has
- Normal weight Obese (50 ng = 125 nanomole)
Download the PDF from VitaminDWiki
Wonder why one had a negative response and why two responded poorly
One of more of the following: Obesity?. Black?, Gut?, Genes?, failure to take the vitamin D?, winter?, become sick?
Obese, African-American (AA) adolescents are at increased risk for vitamin D deficiency. The primary objective of this pilot study was to examine the effect of vitamin D supplementation upon 25-hydroxy vitamin D (25OHD) levels in obese, AA adolescents.
A randomized, double-blinded, controlled pilot study included 26 obese (BMI ≥ 95%ile), vitamin D deficient (25OHD < 20 ng/mL), pubertal AA adolescents (ages 12–17). Subjects received cholecalciferol 1000 IU or 5000 IU daily for 3 months. Serum 25OHD, vitamin D binding protein, parathyroid hormone, and cardiometabolic risk markers were obtained at baseline and post-treatment.
Of 39 subjects enrolled, 26 (67%) were vitamin D deficient (mean 25OHD 12.0 ± 3.8 ng/mL) at baseline and were randomized, with 22 completing the study. Sex, age, season, pubertal stage, BMI, insulin resistance (HOMA-IR) and 25OHD were similar at baseline between the 1000 IU and 5000 IU groups. Post-treatment, 25OHD increased less in the 1000 IU group (5.6 ng/mL, p = 0.03) vs. the 5000 IU group (15.6 ng/mL, p = 0.002). 83% of the 5000 IU group and 30% of the 1000 IU group reached post-treatment 25OHD ≥ 20 ng/mL (p = 0.01); 50% of the 5000 IU group, but no subject from the 1000 IU group, achieved 25OHD ≥ 30 ng/mL (p = 0.009). We detected no group differences in mineral metabolites or cardiometabolic risk markers following supplementation.
Cholecalciferol dosing in excess of the current Institute of Medicine dietary reference intakes was required to achieve 25OHD levels ≥20 ng/mL in obese, AA adolescents. Supplementation of 5000 IU may be required to achieve the desired goal.
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