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Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily – June 2018

Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents

J. of Clinical & Translational Endocrinology, Vol 12, June 2018, Pages 1-7. https://doi.org/10.1016/j.jcte.2018.03.001
Sheela N.Maggeb1 Divya Prasada Babette S.Zemelc Andrea Kellya

VitaminDWiki

Items in both categories Obesity and Dark Skin are listed here:


Overview Obesity and Vitamin D contains the following summary__

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  • Normal weight     Obese     (50 ng = 125 nanomole)

 Download the PDF from VitaminDWiki
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Wonder why one had a negative response and why two responded poorly
One of more of the following: Obesity?. Black?, Gut?, Genes?, failure to take the vitamin D?, winter?, become sick?

Obese, African-American (AA) adolescents are at increased risk for vitamin D deficiency. The primary objective of this pilot study was to examine the effect of vitamin D supplementation upon 25-hydroxy vitamin D (25OHD) levels in obese, AA adolescents.

Methods
A randomized, double-blinded, controlled pilot study included 26 obese (BMI ≥ 95%ile), vitamin D deficient (25OHD < 20 ng/mL), pubertal AA adolescents (ages 12–17). Subjects received cholecalciferol 1000 IU or 5000 IU daily for 3 months. Serum 25OHD, vitamin D binding protein, parathyroid hormone, and cardiometabolic risk markers were obtained at baseline and post-treatment.

Results
Of 39 subjects enrolled, 26 (67%) were vitamin D deficient (mean 25OHD 12.0 ± 3.8 ng/mL) at baseline and were randomized, with 22 completing the study. Sex, age, season, pubertal stage, BMI, insulin resistance (HOMA-IR) and 25OHD were similar at baseline between the 1000 IU and 5000 IU groups. Post-treatment, 25OHD increased less in the 1000 IU group (5.6 ng/mL, p = 0.03) vs. the 5000 IU group (15.6 ng/mL, p = 0.002). 83% of the 5000 IU group and 30% of the 1000 IU group reached post-treatment 25OHD ≥ 20 ng/mL (p = 0.01); 50% of the 5000 IU group, but no subject from the 1000 IU group, achieved 25OHD ≥ 30 ng/mL (p = 0.009). We detected no group differences in mineral metabolites or cardiometabolic risk markers following supplementation.

Conclusions
Cholecalciferol dosing in excess of the current Institute of Medicine dietary reference intakes was required to achieve 25OHD levels ≥20 ng/mL in obese, AA adolescents. Supplementation of 5000 IU may be required to achieve the desired goal.

Created by admin. Last Modification: Wednesday July 11, 2018 03:29:06 UTC by admin. (Version 4)

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10149 Obese black teens.jpg admin 10 Jul, 2018 21:45 40.55 Kb 12
10148 Obese black teens.pdf PDF 2018 admin 10 Jul, 2018 21:45 331.95 Kb 4
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