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Less weight gain if add Vitamin D, even if have a high fat diet (in rats) – RCT Dec 2017

The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats

Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Ghazaleh Nameni, Ghazaleh Hajiluian and Parviz Shahabi
BMC NeuroscienceBMC series – 201718:81, https://doi.org/10.1186/s12868-017-0400-1© The


This study echos many previous studies with humans - less weight gain and even lose weight with vitamin D

Overview Obesity and Vitamin D contains the following summary

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Rats gained less weight if take Vitamin D (independant of amount of fat in diet)


Obesity induced brain inflammation is associated with cognitive disorders. We aimed to investigate the influence of vitamin D on hypothalamus and hippocampus inflammatory response in high-fat diet induced obese rats.

In the beginning of the study, 40 rats were divided into two groups: control diet and high fat diet (HFD) for 16 weeks; then each group subdivided into two groups including: N, ND + vitamin D, HFD and HFD + vitamin D. Vitamin D supplementation was done for 5 weeks at 500 IU/kg dosage. IL-6, IL-1β, NF-Kβ and acetylcholine (ACH) and brain derived neurotropic factor (BDNF) concentrations in hippocampus and hypothalamus homogenate samples were measured by commercial ELISA kits.

Vitamin D administration, reduced food intake and weight gain in studied groups (P < 0.001). Vitamin D reduced hippocampus acetylcholine concentrations in ND + vitamin D group (P < 0.001). High fat diet increased hippocampus IL-6 concentrations significantly (P < 0.05) compared with normal diet receiving groups. Vitamin D could not have significant effects on IL-6 concentrations. Vitamin D administrations reduced IL-1β, NF-Kβ and acetylcholine concentration and BDNF concentrations in ND + vitamin D compared with ND group. These reductions were not significant in HFD + vitamin D versus HFD group.

According to our results, vitamin D reduced food intake and weight gain and modulated the HFD induced inflammatory response in hippocampus and hypothalamus of high fat diet induced obesity. Therefore, this neurosteroid, can be suggested as a supplemental therapeutic tool in prevention of obesity related cognitive and neurodegenerative problems.

Created by admin. Last Modification: Tuesday July 17, 2018 14:20:34 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
9102 Weight gain.jpg admin 02 Jan, 2018 12:57 23.65 Kb 665
9100 High fat diet.pdf PDF 2017 admin 02 Jan, 2018 12:49 897.63 Kb 919