The effects of three regimens of cholecalciferol (vitamin D3) supplementation on vitamin D deficiency in non-obese and obese females.
Arch Med Sci Atheroscler Dis. 2018 Mar 27;3:e60-e67. doi: 10.5114/amsad.2018.74784
Imga NN1, Berker D1, Can B1, Guler S1.
Daily or Weekly 50,000 IU oral Vitamin D for 8 weeks
- One pill every two weeks gives you all the vitamin D most adults need
- Which includes "32 health problems fought by 50,000 Vitamin D weekly "
A samplng of the many RCT which found weekly to work well (often 50,000 IU was used)
- Vitamin D dosing - weekly may be better than daily – video Aug 2018
- 50,000 IU of vitamin D weekly following cardiac failure helps – RCT 2014
- Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017
- Weekly Vitamin D to mother after birth much better than daily - RCT Aug 2018
- Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT 2019
- Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D – Jan 2019
- Urgency Urinary Incontinence in senior black women decreased 40 percent by weekly 50,000 IU vitamin D – RCT Dec 2018
- Attention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT Nov 2018
- Depression in seniors treated by weekly 50,000 IU of vitamin D – RCT Sept 2018
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Note: vitamin D levels dropped by the 6th month asthere was no dosing after the 8th week
Vitamin D deficiency is a common health problem worldwide and tends to be a risk factor for all-cause mortality. We evaluated the effect of continuous low-dose oral daily and loading dose of oral weekly and loading monthly intramuscular (IM) vitamin D3 regimens on circulating levels of total 25(OH)D and in vitamin D deficient females, and between non-obese and obese subgroups.
MATERIAL AND METHODS:
A total of 231 vitamin D deficient females were included to the study. According to treatment regimen, patients were divided into three groups:
- daily continuous oral,
- loading dose of weekly oral
- and monthly intramuscular.
All patients in treatment groups were divided into non-obese (105) and obese (126) groups. Serum 25(OH)D and parathormone (PTH) levels were evaluated at baseline and at the third and sixth month.
In obese patients oral weekly loading regimen and in non-obese patients oral daily continuous regimens were found to be more potent. Baseline PTH levels decreased when compared with the third and sixth months (p < 0.001), but between the third and sixth months it was not changed (p = 0.783).
- Oral daily regimen in non-obese patients and
- loading weekly oral regimen in obese patients
were more effective in achieving the target levels of 25(OH)D concentration above 30 ng/ml and provided a stable plasma vitamin D concentration over a long period of time.Title was revised August 2019 causing the visitor count to reset.
There have actually been