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Obese responded to weekly vitamin D better than non-obese – RCT March 2018

The effects of three regimens of cholecalciferol (vitamin D3) supplementation on vitamin D deficiency in non-obese and obese females.

Arch Med Sci Atheroscler Dis. 2018 Mar 27;3:e60-e67. doi: 10.5114/amsad.2018.74784
Imga NN1, Berker D1, Can B1, Guler S1.


This study: Daily vs. Weekly 50,000 IU oral Vitamin D for 8 weeks

Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs

A sampling of the many RCT which found weekly to work well (often 50,000 IU was used)

Weekly may be BETTER than daily

Non weekly

1 or 2 per month may be BETTER than daily

Take vitamin D3 daily, weekly, or bi-weekly has the following

  • Notional chart for Vitamin D supplementation for levels < 30 nanograms

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=2475

  • Notional chart of Vitamin D benefit vs dosing frequency for > 50 nanograms

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=2475
Notional chart for Vitamin D supplementation for levels < 30 nanograms
see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=2475

 Download the PDF from VitaminDWiki
Note: vitamin D levels dropped by the 6th month asthere was no dosing after the 8th week

Vitamin D deficiency is a common health problem worldwide and tends to be a risk factor for all-cause mortality. We evaluated the effect of continuous low-dose oral daily and loading dose of oral weekly and loading monthly intramuscular (IM) vitamin D3 regimens on circulating levels of total 25(OH)D and in vitamin D deficient females, and between non-obese and obese subgroups.

A total of 231 vitamin D deficient females were included to the study. According to treatment regimen, patients were divided into three groups:

  • daily continuous oral,
  • loading dose of weekly oral
  • and monthly intramuscular.

All patients in treatment groups were divided into non-obese (105) and obese (126) groups. Serum 25(OH)D and parathormone (PTH) levels were evaluated at baseline and at the third and sixth month.

In obese patients oral weekly loading regimen and in non-obese patients oral daily continuous regimens were found to be more potent. Baseline PTH levels decreased when compared with the third and sixth months (p < 0.001), but between the third and sixth months it was not changed (p = 0.783).


  • Oral daily regimen in non-obese patients and
  • loading weekly oral regimen in obese patients

were more effective in achieving the target levels of 25(OH)D concentration above 30 ng/ml and provided a stable plasma vitamin D concentration over a long period of time.

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Created by admin. Last Modification: Wednesday December 25, 2019 14:55:16 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
11896 Weekly.jpg admin 02 May, 2019 20:15 34.44 Kb 573
11895 Weekly.pdf PDF 2018 admin 02 May, 2019 20:14 298.20 Kb 642