Hypertension reduced by Vitamin D if taken daily to every 14 days by who were deficient – June 2022

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Is Vitamin D Supplementation an Effective Treatment for Hypertension?

Curr Hypertens Rep. 2022 Jun 23. doi: 10.1007/s11906-022-01204-6
Songcang Chen 1, Gio Gemelga 2, Yerem Yeghiazarians 2

Table of Contents PDF

Purpose of the review: Results from epidemiological studies suggest that vitamin D (VD) deficiency (VDD) may be a cause of hypertension (HTN). However, the results of randomized clinical trials (RCTs) designed to address the impact of VD supplementation on reducing blood pressure (BP) remain equivocal. To determine whether VD might serve as a beneficial treatment option for a specific subset of hypertensive patients, we performed a stratified analysis of RCT data and addressed problems associated with some methodological issues.

Recent findings: HTN is caused by multiple factors. VDD may be one of the factors contributing to the development of this disorder. There are more than 70 RCTs that examined the impact of VD supplementation on BP. These RCTs can be classified into four groups based on their respective study populations, including participants who are

• (1) VD-sufficient and normotensive,
• (2) VD-deficient and normotensive,
• (3) VD-sufficient and hypertensive, and
• (4) VD-deficient and hypertensive.

Our evaluation of these studies demonstrates that VD supplementation is ineffective when used to reduce BP in VD-sufficient normotensive subjects. VD supplementation for five years or more may reduce the risk of developing HTN specifically among those with VDD. Interestingly, findings from 12 RCTs indicate that daily or weekly supplementation, as opposed to large bolus dosing, results in the reduction of BP in VD-deficient hypertensive patients. Our ongoing research focused on elucidating the mechanisms of VDD-induced HTN will ultimately provide evidence to support the development of etiology-specific prevention and treatment strategies focused on HTN in the VD-deficient population.
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VitaminDWiki - Hypertension category contains

167 items in the category HYPERTENSION

see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies

• Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017
• Hypertension risk reduced 4X if adequate level of Vitamin D – July 2024
• COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
• Magnesium reduces hypertension - FDA allows claim - Jan 2022
• Drug-resistant hypertension 3.5 X more likely if low vitamin D – March 2020
• High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019
• Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
• Hypertension is associated with low vitamin D in some groups – meta-analysis April 2015
• Off Topic – Hypertension in 42 percent of adults (new definition: 130 mm Hg) – Feb 2018
  • Men aged 40-59 59%, age >60 75%: National Health and Nutrition Examination Survey, 2017–2018

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HT related to Pregnancy 38+, Intervention 15+, Cardio. 14+, Diabetes 13+, Stroke 10+, Mg 9+ categories

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VitaminDWiki - 17 studies in both categories Hypertension and Intervention

This list is automatically updated

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VitaminDWiki - 15 studies in both categories Hypertension and Magnesium

This list is automatically updated