Vitamin D and nifedipine in the treatment of Chinese patients with grades I–II essential hypertension: A randomized placebo-controlled trial
Atherosclerosis, Volume 235, Issue 1, Pages 102–109, July 2014, http://dx.doi.org/10.1016/j.atherosclerosis.2014.04.011
Wei Ren Chen1, Zhi Ying Liu1, Yang Shie chen_weiren at sina.com , Da Wei Yin, Hao Wang, Yuan Sha, Yun Dai Chen
1These authors contributed equally to this work.
Received: December 4, 2013; Received in revised form: March 28, 2014; Accepted: April 7, 2014; Published Online: April 30, 2014, DOI:
•We planned to research the effect of vitamin D and nifedipine in the treatment of patients with essential hypertension.
•Vitamin D supplementation can reduce blood pressure in patients with hypertension.
•Vitamin D supplementation can be an adjuvant therapy for patients with grade I to II essential hypertension.
Low vitamin D status has been shown to be associated with hypertension. We planned to research the effect of vitamin D and nifedipine in the treatment of patients with essential hypertension.
Patients with grades I–II essential hypertension were enrolled in this single-center, double-blind, placebo-controlled trial in Beijing. All patients received a conventional antihypertensive drug (nifedipine, 30 mg/d). One hundred and twenty-six patients were randomly assigned to receive vitamin D (n=63, 2000 IU/d) or a placebo (n=63) as an add-on to nifedipine, by the method of permutated block randomization. Ambulatory blood pressure monitoring was performed at baseline (month 0), at month 3 and at month 6.
In vitamin D supplementation group, there was a significant increase in mean 25-hydroxyvitamin D levels from baseline (19.4±11.6 ng/ml) to 6 months (34.1±12.2 ng/ml; p<0.001). At 6 months, the primary end points, a difference in the fall of 24-h mean blood pressure, between the groups was
- −6.2 mmHg (95% CI −11.2; −1.1) for systolic blood pressure (p<0.001) and
- −4.2 mmHg (95% CI −8.8; −0.3) for diastolic blood pressure (p<0.001)
under intention to treat analysis.
In patients with vitamin D <30 ng/ml at baseline (n=113), 24-h mean blood pressure decreased by 7.1/5.7 mmHg (p<0.001). Safety and tolerability were similar among the two groups.
Vitamin D supplementation can reduce blood pressure in patients with hypertension, it can be an adjuvant therapy for patients with grades I–II essential hypertension.
Clinical Trial Registration: This study was registered in the Chinese Clinical Trial Registry, it is available in Website: http://www.chictr.org/cn/; Registration number: ChiCTR-ONC-13003840.
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