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Hypertension reduced by Magnesium plus 3,000 IU of vitamin D for 12 weeks – RCT July 2022


The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial

Nutrition. Jul-Aug 2022;99-100:111674. doi: 10.1016/j.nut.2022.111674
May M Cheung 1, Rosemary D Dall 2, Patricia A Shewokis 3, Asma Altasan 4, Stella L Volpe 5, Renee Amori 6, Harpreet Singh 7, Deeptha Sukumar 8

Vitamin D levels raised by 6 ng when Mg added

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Vitamin D + Mg reduced HT the most (Blurry Google Images)

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Objective: Poor vitamin D and magnesium status is observed in individuals who are overweight and obese (Owt/Ob) and is often associated with a heightened risk of cardiovascular disease. Magnesium is a cofactor that assists vitamin D metabolism. We aimed to determine the efficacy of a combined magnesium and vitamin D regimen compared with vitamin D only on increasing serum 25-hydroxyvitamin D (25OHD) concentrations and the effects of these supplements on cardiometabolic outcomes.

Methods: This 12-week double-blinded randomized controlled trial had three treatment arms: magnesium + vitamin D (MagD; 360 mg magnesium glycinate + 1000 IU vitamin D 3 × daily), vitamin D only (VitD; 1000 IU vitamin D 3 × daily), and placebo. A total of 95 Owt/Ob participants were randomized into one of these three study arms. Anthropometry, dietary intake, concentrations of serum 25OHD, serum parathyroid hormone (PTH), serum inflammatory markers, and blood pressure were obtained at baseline and week 12.

Results: The MagD group experienced the greatest increase in serum 25OHD concentrations (6.3 ± 8.36 ng/mL; P < 0.05). There was a decrease in systolic blood pressure (7.5 ± 8.26 mmHg; P < 0.05) for individuals who had a baseline systolic blood pressure of >132 mmHg in the MagD group. There were no statistically significant treatment effects on serum PTH concentrations and markers of inflammation.

Conclusions: A combined MagD treatment may be more effective in increasing serum 25OHD concentrations compared with VitD supplementation alone in Owt/Ob individuals.


VitaminDWiki - Hypertension category contains

164 items in the category HYPERTENSION

see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies


VitaminDWiki - 17 studies in both categories Hypertension and Intervention

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VitaminDWiki - 9 studies in both categories Hypertension and Vitamin D Receptor

A poor Receptor will restrict how much vitamin D actually gets to the cells
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VitaminDWiki - 11 studies in both categories Hypertension and Magnesium

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Created by admin. Last Modification: Monday June 13, 2022 01:46:43 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
17850 Combined blood pressure.jpg admin 12 Jun, 2022 45.93 Kb 370
17849 Mg combined bar chart.jpg admin 12 Jun, 2022 22.82 Kb 345