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Heart cells may be repaired by vitamin D (nanosensors observed nitric oxide in dish) - Jan 2018

Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D3 – clinical implications for cardiovascular diseases

International Journal of Nanomedicine,19 January 2018 Volume 2018:13 Pages 455—466, DOI https://doi.org/10.2147/IJN.S152822
Alamzeb Khan, Hazem Dawoud, Tadeusz Malinski
Department of Chemistry & Biochemistry, Nanomedical Research Laboratories, Ohio University, Athens, OH, USA

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Response to injecting a small amount of vitamin D to heart cells - one of many charts

Image

Background: Clinical studies indicate that vitamin D3 improves circulation and may have beneficial effects in hypertension. This study uses nanomedical systems to investigate the role of 1,25-dihydroxy vitamin D3 in the preservation/restoration of endothelial function in an angiotensin II (Ang II) cellular model of hypertension.

Methods: 1,25-dihydroxy vitamin D3-stimulated nitric oxide (NO) and peroxynitrite (ONOO-) concentrations were measured in situ with nanosensors (200–300 mm diameter with a detection limit of 1 nM) in human umbilical vein endothelial cells of African American (AA) and Caucasian American (CA) donors exposed to Ang II. The balance/imbalance between NO and ONOO- concentrations ([NO]/[ONOO-]) was simultaneously monitored and used as an indicator of endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction.

Results: [NO]/[ONOO-] imbalance in Ang II-stimulated dysfunctional endothelium was 0.20±0.16 for CAs and 0.11±0.09 for AAs. Uncoupled eNOS and overexpression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contributed to high production of ONOO-. Vitamin D3 treatment reversed [NO]/[ONOO-] to 3.0±0.1 in CAs and 2.1±0.1 in AAs – exceeding that observed in normal endothelium. Vitamin D3 restored uncoupled eNOS and endothelial function by increasing cytoprotective NO and decreasing the cytotoxic ONOO-. The beneficial effect of vitamin D3 is associated with a favorable rate of NO and ONOO- release, restoration of the [NO]/[ONOO-] and the overall decrease in the overexpression of eNOS, inducible nitric oxide synthase and NADPH oxidase. This effect of vitamin D3 may prove to be beneficial in the treatment of hypertension and other cardiovascular diseases, including heart failure, myocardial infarction, vasculopathy, stroke and diabetes.

Vitamin D-3 could 'reverse' damage to heart Med News Today

  • . . "nanosensors, or tiny probes that are 1,000 times smaller than the thickness of human hair. . "
  • "The findings suggest that vitamin D-3 is a powerful trigger of nitric oxide, which is a molecule that plays an important signaling role in the control of blood flow and the formation of blood clots in blood vessels"
  • "They suggest that vitamin D-3 has the potential to significantly reverse the damage that high blood pressure, diabetes, atherosclerosis, and other diseases inflict on the cardiovascular system."
  • Study author "This is a very inexpensive solution to repair the cardiovascular system. We don't have to develop a new drug. We already have it."

Helping the heart as much or more than Vitamin D

Magnesium and Cardiovascular in both categories

Omega-3 and Cardiovascular (items in both categories)

Plant-based diet McGregor 2017 - perhaps at 100X reduction in heart problems

Created by admin. Last Modification: Thursday February 1, 2018 22:43:19 UTC by admin. (Version 12)

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9292 NO response.jpg admin 01 Feb, 2018 17:27 22.45 Kb 132
9291 Nanosensor Vit D restores heart.pdf PDF 2018 admin 01 Feb, 2018 17:19 1.03 Mb 105
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