Table of contents
- Video highlights
- Her comments on sections of the inteview
- VitaminDWiki - Vitamin D and Omega-3 category starts with
- VitaminDWiki - Omega-3 and cardiovascular
- VitaminDWiki - Omega-3 and Virus
- VitaminDWiki - Virus Videos
- VitaminDWiki - COVID-19 treated by Vitamin D - studies, reports, videos
- VitaminDWiki - PATRICK in the title (10 as of Dec 2021)
- 00:01:59 - How early studies on dietary fats and cholesterol levels spawned the field of omega-3 research.
- 00:06:44 - How flaws in early study designs may have led to inconsistencies in findings.
- 00:11:39 - How pre-operative omega-3 loading reduces blood loss during surgery.
- 00:14:32 - How standards of "normal" bleeding time may be abnormally high in Western countries.
- 00:16:26 - How different types of omega-3s share structural similarities but not cardioprotective effects.
- 00:20:28 - How genetic engineering of plants may yield abundant, sustainable omega-3s in the future.
- 00:22:42 - How the Omega-3 Index was created.
- 00:27:38 - How red blood cell concentrations of omega-3s better reflect long-term omega-3 status than plasma measures.
- 00:32:06 - How genetic variants influence omega-3 needs.
- 00:50:08 - How people with high omega-3 concentrations are less likely to die prematurely.
- 01:00:27 - How byproducts of omega-3 metabolism reduce inflammation.
- 01:13:17 - How people with high omega-3 concentrations are half as likely to die from COVID-19.
- 01:15:35 - How DHA (an omega-3) keeps the SARS-CoV-2 spike protein from entering cells.
- 01:18:14 - How concerns over the omega-6/omega-3 ratio may be unfounded.
"But interesting to me is that all these other causes of death – from electrocution to suicide, to car accidents, to kidney failure, you know, everything people died of – the higher the omega-3, the lower the risk." - Dr. Bill Harris
Low cardiovascular disease incidence observed in Inuits.
Scientific interest in omega-3 fatty acids first emerged about 50 years ago, when Danish researchers Hans Olaf Bang and Jørn Dyerberg sought answers to why the Inuit, an indigenous people living in northwestern Greenland, had the world's lowest incidence of cardiovascular disease-related deaths – despite having what seemed like a rather unhealthy diet.
Bang and Dyerberg eventually attributed the Inuit's cardiovascular health to their high blood concentrations of omega-3 fatty acids, effectively putting omega-3s on the nutrition map. Nowadays omega-3s and their alphabet-soup names, EPA, DHA, and ALA, are practically household words.
The omega-3 research was gaining traction in other places, too. Dr. Bill Harris and other scientists in the United States also began studying omega-3s, looking first at their effects on platelet aggregation – an early step in the development of atherosclerosis – and eventually expanding their research to investigate the omega-3s' effects on aspects of cardiovascular, neurocognitive, immunological, and respiratory health, among others.
Despite some inconsistencies in the findings from interventional studies (likely due to variations in study design), the epidemiological data have been remarkably consistent, revealing robust links between omega-3 intake and reduced risk of premature death.
Is there an omega-3 intake-associated mechanism affecting COVID-19 severity?
An emerging area of interest in omega-3 research centers on immunity, specifically against SARS-CoV-2, the virus that causes COVID-19. Recent epidemiological data suggest that people with high omega-3 blood concentrations are about half as likely to die from COVID-19 compared to those with low concentrations. And computer modeling suggests that the omega-3 DHA prevents the spike protein – the primary antigenic component of SARS-CoV-2 – from binding to cells and gaining entry. These findings, if replicated in vivo, can have huge relevance for managing the global pandemic – and saving millions of lives.
Resolving and reducing inflammation may be central to many benefits of omega-3.
What's driving the healthful effects of omega-3s? An abundance of evidence points to a large class of byproducts of omega-3 metabolism called specialized pro-resolving mediators, or SPMs. These unique molecules actively seek out and reduce the inflammation that drives many chronic diseases.
Of course, some scientists and healthcare professionals have expressed concerns about possible risks associated with omega-3s. For example, it's well known that omega-3s extend bleeding time and slow clot formation, an effect often referred to as "blood-thinning," which could increase bleeding risks following trauma or during surgery. But these concerns haven't panned out, and data indicate that the effect of omega-3s on bleeding time is similar to that achieved with aspirin, the drug of choice for most people at risk for clots.
Similarly, some studies showed that the ratio of omega-6s to omega-3s in blood was cause for concern. But Dr. Harris explains that the concerns are likely unfounded. Rather than focusing on decreasing omega-6 intake to improve the ratio, most people would probably benefit from increasing omega-3 intake instead, to improve overall blood concentrations.
Improving omega-3 index values may reduce early death.
Dr. Harris and his colleague, Dr. Clemens von Schacky, recognized the need to quantify blood concentrations of omega-3s that increased (or decreased) risk for cardiovascular disease and related death. They identified a target omega-3 level, dubbed the "Omega-3 Index," that some have suggested is a measurable risk factor for sudden cardiac death.
In general, people who have healthy omega-3 status, especially those above 8% omega-3 content of red blood cell membranes, are far less likely to die from all causes of premature death. The converse is also true: Lower levels markedly increase a person's risk of death.
How much omega-3 do humans need to achieve these levels and reap the benefits?
Dietary and supplemental forms of the fatty acids differ in their content and quality, and people may carry genetic variants (such as APOE4) or exhibit other factors that influence individual responses to omega-3s. However, a combined dose of EPA & DHA between 1.75 and 2.5 grams per day takes most people from 4% to 8%. In other words, into the target range generally associated with improved outcomes.
Unfortunately, the human need for omega-3s could feasibly outstrip the available, non-renewable sources. Genetic engineering of plants that produce high-yield – and high quality – EPA and DHA show promise as a strategy to meet growing needs.
A robust and growing body of evidence demonstrates that omega-3 fatty acids are essential nutrients that play critical roles in multiple aspects of human health. In this episode, Dr. Harris and I discuss the importance of omega-3s, the mechanisms that underlie their effects, and how quantifying them may provide a marker for cardiovascular disease risk.
VitaminDWiki - Vitamin D and Omega-3 category starts with
- Atrial Fibrilation in VitaminDWiki
- Omega-3 reduced cardiovascular deaths by 16 percent (427,678 people) – March 2020
- Synthetic EPA drug recommended to FDA for Cardio (Omega-3 is 8 X better) – Nov 2019
- Omega-3 reduces heart problems by ~5 percent – meta-analysis by Heart Association Oct 2019
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Few people have enough EPA (an Omega-3) to reduce heart failures – July 2019
- Another Nail in the Coffin for Fish Oil Supplements (nope) – JAMA April 2018
- Omega-3 provides many cardiovascular benefits – April 2018
- Omega-3 helps the heart, AHA class II recommendation, more than 1 gm may be needed – March 2018
- 3 days of Omega-3 before cardiac surgery reduced risk of post-op bleeding by half – RCT March 2018
- Perhaps the Omega-3 optimal level is 10 percent, not 8 – Feb 2018
- Omega-3 Cardiovascular meta-analysis has at least 5 major problems – Jan 2018
- Benefits of Omega-3 beyond heart health - LEF Feb 2018
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
- Cardiovascular problems reduced by low dose aspirin and perhaps Omega-3 (also Vit K) – Sept 2017
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- For every Omega-3 dollar there is a 84 dollar savings in Cardiovascular costs - Foster and Sullivan April 2016
- High dose Omega-3 probably reduces heart problems – American Heart Association – March 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Omega-3 – need more than 1 gram for a short time to reduce Cardiovascular Disease – Nov 2016
- Omega-3 is vital for health, mail-in test is low cost and accurate
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015
- Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014
- Omega-7 - in addition to Omega-3
- Omega-3 reduces Coronary Heart Disease - infographic June 2014
- Cardiovascular diseases – conflicting data on benefits of Omega-3 and vitamin D – Feb 2014
- Cardiovascular system benefits from both Omega-3 and vitamin D – Dec 2012
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
- Omega-3 does not help heart patients – meta-analysis Sept 2012
- COVID-19 decreased risk if add Vitamin D, A, C, NAC, Se, Zn, or Omega-3 – Dec 2021
- High-dose Omega-3 fought COVID in 2 hospital trials (6x reduction in ICU, reduced time) – Masterjohn Oct 2021
- COVID-19 risk reduced 4X by each of: Vitamin D, Omega-3, Curcumin, Zinc
- Omega-3 reduces risk of COVID-19 - many studies
- How Vitamin D, Magnesium, Omega-3 and Zinc prevent and treat COVID-19 and many other health problems – June 2021
- Many supplements appear to fight COVID-19 – vitamin D cited 52 times – May 2021
- COVID-19 Cytokine storms attenuated by Vitamin D, Omega-3, Mg, Resveratrol, etc – April 2021
- COVID-19 ICU survival rate increased 7X by daily Omega-3 – RCT March 2021
- 4X fewer COVID-19 deaths in those having high Omega-3 index – Jan 6, 2021
- Vitamin D and COVID - Davies, Benskin (Dark Horse video with transcript) - Dec 27, 2021
- Boost Your Immune System, Fight Viruses - Dr. Seheult with transcript - Oct 29, 2021
- Vitamin D and a Dr. in Israel - Campbell video and transcript - Dec 11, 2021
- COVID vaccines produce blood antibodies, not the needed mucosal antibodies - Dec 7, 2021
- Omega-3 decreases heart disease and COVID: Harris and Patrick, video and transcript - Dec 2021
- Vitamin D probably has a Role in Cancer, CVD, and COVID - video and transcript Dec 1, 2021
- Discussion of COVID and 50 ng of Vitamin D (video and transcript)– Dr. Campbell Nov 17, 2021
- Dr. McCullough on COVID-19: vaccine problems, home treatment – video, slides, transcript – Oct and Dec 2021
- Long-haul, VAERS, Ivermectin, vaccines, etc. Drs. Seheult, Patrick: Video with table of contents - Sept 17, 2021
- Immune system - great 11-minute animated video - Aug 2021
- In-home testing of viral load, etc. Dr. Topol interview with transcript – Aug 11, 2021
- Initial efficacy of vaccines against COVID-Delta - July 20, 2021
- COVID-19 doctors not allowed to use treatments that work - Dr McCullough Video and transcript May 2021
- Vitamin D fights many health symptoms, including COVID-19: Dr. Mahtani video and transcript - April 2021
- COVID public health messages 1, 2, and 3 should be - vitamin d vitamin d, vitamin d (video and transcript) - Mar 5, 2021
- COVID-19 fought by Vitamin D or Heat - Drs Seheult and Patrick video - March 3, 2021
- Vitamin D Deficiency and Covid-19: Book by Drs Anderson and Grimes - July 2020
- Vitamin D and COVID-19 webinar - Feb 24, 2021
- Low-cost Ivermectin and Vitamin D fight COVID-19 – Marik video 1 hr – Feb 18, 2021
- Vitamin D and COVID-19: 1 hour simple video - Jan 31, 2021
- Vitamin D helps the immune system fight COVID-19 – video Jan 21, 2021
- Vitamin D, COVID - Campbell and Davis (Video with transcript) - Jan 18, 2021
- COVID 19 Video - Drs. Seheult and Campbell : Lessons Learned and a Look Ahead - Jan 4
- COVID-19 Vitamin D: Overview by Dr. in Sri Lanka (Video and transcript) - Dec 8, 2020
- COVID-19 Vitamin D: Overview of Evidence by Dr. Seheult (Video and transcript) - Dec 10, 2020
- Vitamin D and COVID-19: Video and PDF by Dr. Grant (includes recommendations)- Nov 25, 2020
- Vitamin D and COVID-19 - observational studies found it helps, never hurts - Campbell Oct 31, 2020
- Can vitamin D fight COVID-19 - interview of Dr. Matthews Oct 2020
- COVID-19 and high-dose Vitamin D - Video interview of Dr. Coimbra - May 2020
- COVID-19 prompts awareness of deficiencies of Vitamin D, C and Magnesium - April 6 2020
VitaminDWiki - COVID-19 treated by Vitamin D - studies, reports, videos
As of Jan 10, 2022, the VitaminDWiki page had: 34 trials, 6 trial results, 32 meta-analyses and reviews, 64 observations, 36 recommendations, 55 associations, 89 speculations, 58 videos see related: Governments, HealthProblems, Hospitals, Dark Skins, 26 risk factors are ALL associated with low Vit D, Recent Virus pages Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID
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