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3 days of Omega-3 before cardiac surgery reduced risk of post-op bleeding by half – RCT March 2018

HIGHER PLASMA OMEGA 3 FATTY ACID LEVELS ARE ASSOCIATED WITH REDUCED RISK FOR BLEEDING AFTER CARDIAC SURGERY

Journal of the American College of Cardiology, Volume 71, Issue 11 Supplement, March 2018, DOI: 10.1016/S0735-1097(18)32326-X
Prince Sethi, Emmanuel Akintoye, Paul Thompson, Dariush Mozaffarian and William Harris
March 10, 2018, 10:00 a.m.-10:45 a.m.
Session Title: The Latest on Dyslipidemia Care in the Age of Precision Medicine
Abstract Category: 32. Prevention: Clinical, Presentation Number: 1129-433

 Download the PDF abstract from VitaminDWiki

Background
Omega 3 fatty acids (n-3 FAs) are used for cardiovascular disease prevention. There have been theoretical concerns about n-3 FAs increasing the risk for bleeding, especially during surgery. The OPERA trial was a multi-center, double-blind, randomized trial that tested the effects of n-3 FA supplementation for 2-3 days pre-surgery on post-operative atrial fibrillation. In secondary analyses, the effects of n-3 FA supplementation on bleeding outcomes were evaluated

Methods
Of 1516 patients scheduled for cardiac surgery, data on n-3 FA levels on the morning of surgery was available for 552 patients-280 received n-3FAs and 272 received placebo. We investigated association between circulating plasma n-3 FA levels and 1) risk of postoperative bleeding, and 2) the number of units of blood transfused

Results
The sum of three long-chain n-3 FAs[docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and eicosapentaenoic acid (EPA)] in plasma phospholipids was 4.8% in placebo group and 6.4% in intervention group(p <0.0001). The table shows the risk for postoperative bleeding as a function of plasma n-3FA level quartiles. The number of blood units needed during surgery was analyzed on a continuous basis in a model adjusting for age, sex, BMI, and 4 bleeding-related drugs use. For 1-SD increase in the n-3 FA level, OR (95% CI) was 0.91 (0.88-0.95; p = 0.014)

Conclusion: Higher n-3FA levels were associated with a reduced risk of postoperative bleeding and need for blood transfusion in cardiac surgery

Created by admin. Last Modification: Tuesday March 13, 2018 12:21:59 UTC by admin. (Version 6)

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9500 Omega-3 CARDIAC SURGERY.pdf PDF 2018 admin 13 Mar, 2018 11:59 334.15 Kb 26
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