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Risk of Hip fracture cut in half if Vitamin D was prescribed - Aug 2023

Prescription of vitamin D was associated with a lower incidence of hip fractures

Sci Rep. 2023 Aug 9;13(1):12889. doi: 10.1038/s41598-023-40259-6.
Mitsutaka Yakabe 1, Tatsuya Hosoi 1, Shoya Matsumoto 1, Kenji Fujimori 2 3, Junko Tamaki 4 3, Shinichi Nakatoh 5 3, Shigeyuki Ishii 6 3, Nobukazu Okimoto 7 3, Kuniyasu Kamiya 4 3, Masahiro Akishita 1, Masayuki Iki 8 3, Sumito Ogawa 9 10

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Patients with osteoporosis are prone to fragility fractures. Evidence of the effects of active forms of vitamin D on hip fracture prevention is insufficient. We examined the association between vitamin D prescription and incidence of new fractures using the data of osteoporotic patients from the nationwide health insurance claims database of Japan. The follow-up period was 3 years after entry. The untreated patients were never prescribed vitamin D during follow-up (n = 422,454), and the treated patients had a vitamin D medication possession ratio of ≥ 0.5 at all time points (n = 169,774). Propensity score matching was implemented on these groups, yielding 105,041 pairs, and subsequently, the control and treatment groups were established and analyzed.
The incidence of new fractures was significantly lower in the treatment group compared with the control group (6.25% vs. 5.69%, hazard ratio 0.936 [95% confidence interval 0.904-0.970], p < 0.001*).
By site, hip fractures significantly decreased (0.89% vs. 0.42%, p < 0.001), but not vertebral and radial fractures. Subgroup analysis by vitamin D type showed a significantly lower incidence of total fractures only in alfacalcidol (hazard ratio 0.676 [95% confidence interval 0.628-0.728], p < 0.001*). The results suggest that vitamin D prescription was associated with a reduced incidence of hip fractures.
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74+ Hip fracture etc. studies in VitaminDWiki title

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Items found: 77
Title Modified
Hip fractures 60% more likely in people who drank a lot of milk - Greger Feb 2024 14 Feb, 2024
Hip fracture risk was reduced by 4 times when Vitamin D was added to SERMS - Jan 2024 25 Jan, 2024
Risk of Hip fracture cut in half if Vitamin D was prescribed - Aug 2023 26 Aug, 2023
Hip fractures are predicted by 10 factors – low Vitamin D is the biggest – Aug 2023 11 Aug, 2023
Hip fractures greatly reduced by sunshine, vitamin D, and vitamin K – meta-analysis Sept 2012 23 Dec, 2022
Hip fractures requiring hospitalization cut in half by Vitamin K1 (100 mcg per day) – Sept 2022 17 Dec, 2022
More hip fractures if low vitamin D (2.1X in case-controlled studies) – meta-analysis May 2022 01 Jun, 2022
Less than 3 percent of hip fracture patients prescribed enough Vitamin D to make a difference (Malta in this case) – July 2021 26 Jul, 2021
Recommends vitamin D after hip fracture ( but not enough and no-bone building co-factors) – May 2021 21 May, 2021
Call to action: Vitamin D to prevent of treat hip fracture (50,000 weekly for 8 weeks, then bi-weekly) – Holick July 2020 11 Dec, 2020
Risk factors for death after hip fracture surgery – 7 of the 8 are associated with low vitamin D – Aug 2020 09 Aug, 2020
Guideline following hip fracture – 50000 IU vitamin D daily for 7 days – Jan 2013 07 Jun, 2020
3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020 07 Mar, 2020
Hip surgery with multiple doses of 50,000 IU of vitamin D weekly both before and after – RCT 2023 16 Jan, 2020
Hip fractures not prevented by Vitamin D (800 IU daily or large quarterly or annual doses) – meta-analysis – Dec 2019 21 Dec, 2019
Hip fractures reduced 16 to 33 percent by any amount of Vitamin D and Calcium – Oct 2019 05 Nov, 2019
Hip fracture rate increases in winter (subtropical Australia too) – Aug 2019 10 Aug, 2019
Warning - High intake of Vitamin B12 and B6 found to increase risk of hip fracture by 47 percent - 2019 19 May, 2019
Following hip fracture 2,000 IU of vitamin D daily improved quality of life – Feb 2019 23 Mar, 2019
Hip fractures worse if both high PTH and low Vitamin D – Jan 2019 01 Feb, 2019
Hip fracture recovery best with home exercise plus Vitamin D – RCT Dec 2018 12 Dec, 2018
Death of older hip fracture patients at least 1.6X more likely if low vitamin D – May 2018 19 Nov, 2018
After hip surgery Vitamin D levels dropped by 32 percent – Sept 2018 26 Sep, 2018
France wants to reduce hip fractures by drinking 10 glasses of milk daily – April 2018 01 Apr, 2018
Hip fractures rates have been increasing since 2012 – Feb 2018 12 Feb, 2018
Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017 20 Dec, 2017
Hip fracture risk reduced 6 percent for each daily dairy serving (more if full-fat dairy) – Oct 2017 28 Oct, 2017
France is planning to reduce hip fractures by dairy vitamin D fortification (plan will not work) – 2017 17 Oct, 2017
Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016 23 Aug, 2017
Most Hip fracture patients had low vitamin D and protein (needed for strong bones) – May 2017 18 May, 2017
1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017 19 Apr, 2017
Vitamin D loading dose after hip fracture surgery was great – RCT Aug 2016 06 Apr, 2017
Following a stroke, a hip fracture is 6X more likely if low vitamin D – July 2001 04 Mar, 2017
Gene makes Hip Fracture 2.5X more likely unless get more vitamin D - Aug 2015 12 Nov, 2016
Partial (proximal) hip fracture strongly associated with low Vitamin D – Aug 2016 08 Nov, 2016
24 years ago hip fractures were reduced 24 percent in a large trial using Vitamin D and Ca – Oct 2016 22 Oct, 2016
Kaiser working to decrease hip and other fractures – Nov 2011 22 Oct, 2016
Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015 25 Sep, 2016
Hip fracture risk increased 2.5X if problem with Vitamin D Receptor gene (GC) – March 2014 25 Sep, 2016
Hip fracture 50 percent more likely if low in both vitamin D and vitamin K1 – Dec 2015 26 Dec, 2015
Hip fracture 3X more likely if low vitamin D – Dec 2015 26 Dec, 2015
5X fewer hip fractures from Parkinson – Alzheimer – Stroke with enough sun – June 2011 17 Jul, 2015
7 X more likely to get hip fracture if have highest level of vitamin A – Jan 2003 31 May, 2015
Delirium 2.7 X more likely after hip fracture and low vitamin D – May 2015 27 May, 2015
Hip fractures reduced 30 percent with 800 IU of vitamin D – meta-analysis July 2012 16 Mar, 2015
Hip fracture outcome 5X more likely to be poor if low vitamin D – Jan 2015 16 Mar, 2015
Hip fracture rate varies with latitude (and thus vitamin D) in Sweden – Nov 2013 20 Feb, 2015
Hip Fracture – 5X more likely to have bad outcome if have less than 20 ng of vitamin D – Dec 2014 22 Jan, 2015
Hip replacement 2X more likely if hip bone surgery was during winter (low vitamin D) – Dec 2014 05 Dec, 2014
Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 09 Nov, 2014
Hip fracture – not getting enough vitamin D – 2013 28 May, 2014
Hip fractures reduced 2X to 6X with just 10 minutes of sunlight daily – RCT 2003-2010 04 Dec, 2013
Men with hip fracture were 1.6X more likely to have low vitamin D – Aug 2013 09 Nov, 2013
5X increase in hip fracture rates in 65 years - 1998 27 Aug, 2013
Hip fracture reduced 38 percent with Calcium and just 400 IU of vitamin D – RCT Feb 2013 17 Aug, 2013
20 percent fewer male hip fractures if more Magnesium in the water – July 2013 11 Jul, 2013
Half as many hip fractures if take Calcium, hormones, and a tiny amount of vitamin D – July 2013 26 Jun, 2013
Male Hip fracture 1.65X more likely if low vitamin D – May 2013 01 Jun, 2013
Vitamin D needed to prevent and treat hip fracture, but only 20 percent got any – May 2013 31 May, 2013
Tiger got surgery for hip arthritis – not much sun in the cage – March 2013 23 Mar, 2013
Having less than 25 ng of vitamin D was associated with severe hip fracture – March 2011 30 Jan, 2013
Hip fracture 19 percent less likely with just 4 ng higher level of vitamin D – Dec 2012 20 Dec, 2012
Hip fracture and vitamin D – Health ABC study – May 2012 28 Sep, 2012
Hip surgery followed by 100000 IU then 1000 IU of vitamin D daily – June 2010 31 Aug, 2012
2X to 3X higher hip fracture rate in Asia in past 30 years – Aug 2012 18 Aug, 2012
Cataract surgery resulted in 30 percent fewer hip fractures – July 2012 02 Aug, 2012
Hip fractures in India - editorial with recommendation - Sept 2010 06 Jul, 2012
Women with hip fractures very low on vitamins D3 and K – Mar 2011 06 Jul, 2012
Upper body bones fractured along with hip when extremely low on vitamin D – Sept 2010 24 Jun, 2012
30 percent less chance of dying after hip fracture if take vitamin D and other drugs – 2011 24 Jun, 2012
75 percent of hip fractures associated with vitamin D deficiency - Jan 2011 24 Jun, 2012
Vitamin D 2nd most recommended way to prevent next hip fracture – Nov 2010 23 Jun, 2012
Hip fractures worse if very low on vitamin D – Mar 2011 23 Jun, 2012
Hip fracture patients had only 16 ng of vitamin D – May 2011 23 Jun, 2012
Declining hip fracture rates in the United States – unknown reason – June 2010 23 Jun, 2012
Vitamin K1 reduced hip fracture but Vitamin K2 did not – Aug 2011 23 Jun, 2012
Calcium and vitamin D supplements after hip fracture reduced death rate by 25% – Feb 2011 19 Nov, 2011

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