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Hip surgery with multiple doses of 50,000 IU of vitamin D weekly both before and after – RCT 2023

Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications Clinical Trials datatbase

Active Comparator: High Vitamin D3 Supplementation
Subjects enrolled into Group 2 (high-dose Vitamin D3 supplementation) will receive 50,000 IU of oral Vitamin D3 (Cholecalciferol) twice per week for 1 weeks followed by 50,000 IU once per week for 3 weeks prior to surgery.
After surgery they will receive 50,000 IU of oral Vitamin D3 once per week for 4 weeks followed by 800 IU daily for 8 weeks. Vitamin D3 supplementation will be given for a total of 4 months.

Actual Study Start Date : September 1, 2019
Estimated Primary Completion Date : July 1, 2021
Estimated Study Completion Date : July 1, 2022


This RCT will probably be successful.
Even better success predicted if they had

  1. Use larger repletion dose: 250,000 IU is nice, but 400,000 IU is typical before surgery
  2. Repletion dose were proportional to BMI (dose either being more often of larger)

Items in both categories Trauma-Surgery and Loading Dose are listed here:

Created by admin. Last Modification: Monday June 14, 2021 22:02:32 GMT-0000 by admin. (Version 7)