Non-linear relationship between serum 25-hydroxyvitamin D concentration and subsequent hip fracture.
Osteoporos Int. 2012 Dec 19.
de Koning L, Henne D, Hemmelgarn BR, Woods P, Naugler C.
Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
Serum 25-OH vitamin D levels were compared in 254 hip fracture subjects and 2,402 matched control subjects. There was a significant inverse association between 25-OH vitamin D and hip fracture only between 0 and 70 nmol/L.
Vitamin D is integral to bone metabolism, however the utility of serum 25-OH vitamin D as a risk marker for hip fractures is controversial.
We conducted a case-control study of patients admitted to the hospitals with hip fractures in Calgary, Alberta, (catchment population 1.4 million) between January 1, 2007 and August 31, 2011. We searched the laboratory information system of Calgary Laboratory Services for serum 25-OH vitamin D levels within 6 months prior to admission on patients admitted to hospital with hip fractures. Cases were identified through the Calgary Laboratory Services laboratory information system and were matched to controls for age, sex, and month of testing. The hip fracture-25-OH vitamin D association was examined using multiple linear and spline regression.
Of 305 subjects initially identified with hip fractures, serum 25-OH vitamin D levels were available for 254 (83 %). These were matched to 2,402 control subjects.
We observed a significant (p < 0.01) non-linear relationship such that 25-OH vitamin D was inversely associated with hip fracture only below 70 nmol/L (odds ratio = 0.81 per 10 nmol/L increase; 95 % CI 0.86-0.93).
The utility of 25-OH vitamin D level as a risk marker for hip fracture depends on the cut-off level used and was of potential use only for lower levels of 25-OH vitamin D.
PDF is attached at the bottom of this page
- Overview Fractures and vitamin D
- All items in category Falls or Fractures and Vitamin D
- Hip fractures greatly reduced by sunshine, vitamin D, and Vitamin K – meta-analysis Sept 2012
- Women with hip fractures very low on vitamins D3 and K – Mar 2011
- Hip fractures reduced 30 % with 800 IU of vitamin D – meta-analysis July 2012
- 75 % of hip fractures associated with vitamin D deficiency - Jan 2011Hip fracture 19 percent less likely with just 4 ng higher level of vitamin D – Dec 2012
3524 visitors, last modified 21 Dec, 2012,This page is in the following categories (# of items in each category)