Multiple Sclerosis Journal – Experimental, Translational and Clinical https://doi.org/10.1177/2055217319892291
Martin Biström, Lucia Alonso-Magdalena, Oluf Andersen, ...
Swedish case-control study compared 670 people who got MS vs 670 who did not get MS
Vitamin D levels were taken about 8 years before the MS
15.5% of those WITH MS previously had >30 ng of vitamin D
20.5% of those WITHOUT MS previously had >30 ng of Vitamin D
- Overview MS and vitamin D
- Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis May 2018
- Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013
- Multiple Sclerosis risk increased due to genes - 22nd study – Aug 2017
- Multiple Sclerosis relapses cut in half by bi-weekly 100,000 IU of Vitamin D – RCT 2019
UV and Sunshine reduces MS risk
- Multiple Sclerosis 2X more likely if low winter UV – June 2018
- Multiple Sclerosis half as likely if get plenty of sunshine (not a news item) – March 2018
Other things also help
- Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT July 2018
- Multiple Sclerosis 40 percent less likely if consume tinned fish (Vitamin D and Omega-3) – Sept 2019
- Resveratrol treats Multiple Sclerosis and other autoimmune diseases – many studies
- Not a single case of multiple sclerosis in 15,000,000 people (plant-based diets)
High Dose Vitamin D and cofactors
- The use of high dose Vitamin D (Coimbra Protocol) for multiple sclerosis in Germany – 2019
- Successful high dose vitamin D (Coimbra Protocol) should be evaluated – June 2019
- Comparing High-dose vitamin D therapies MS and other health problems
Number of MS studies which are also in other categories
20 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells 11 studies in Vitamin D Receptor - gene which restricts D from getting to the cells 5 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells 19 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS
High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals.
Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent.
Prospectively drawn blood samples from individuals later developing relapsing–remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry.
High levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50–0.93).
These findings further support a role for vitamin D in MS aetiology.
- 1. Munger, KL, Levin, LI, Hollis, BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006; 296: 2832–2838.
- 2. Salzer, J, Hallmans, G, Nyström, M, et al. Vitamin D as a protective factor in multiple sclerosis. Neurology 2012; 79: 2140–2145.
- 3. Munger KL, Hongell K, Åivo J, et al. 25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort. Neurology 2017; 89: 1578 LP – 1583.
- 4. Mokry, LE, Ross, S, Ahmad, OS, et al. Vitamin D and risk of multiple sclerosis: a Mendelian randomization study. PLOS Med 2015; 12: e1001866.
- 5. Rhead, B, Bäärnhielm, M, Gianfrancesco, M, et al. Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Neurol Genet 2016; 2: e97.
- 6. Simpson, S, van der Mei, I. Vitamin D deficiency is an etiological factor for MS – commentary. Mult Scler 2019; 25: 641–643.
- 7. Brink, M, Johansson, L, Nygren, E, et al. Vitamin D in individuals before onset of rheumatoid arthritis – relation to vitamin D binding protein and its associated genetic variants. BMC Rheumatol 2018; 2: 26.
- 8. Ramnemark, A, Norberg, M, Pettersson-Kymmer, U, et al. Adequate vitamin D levels in a Swedish population living above latitude 63°N: the 2009 Northern Sweden MONICA study. Int J Circumpolar Health 2015; 74: 27963.
- 9. Snellman, G, Melhus, H, Gedeborg, R, et al. Determining vitamin D status: a comparison between commercially available assays. PLoS One 2010; 5: e11555.
- 10. Marklund, M, Wu, JHY, Imamura, F, et al. Biomarkers of dietary omega-6 fatty acids and incident cardiovascular disease and mortality. Circulation 2019; 139: 2422–2436.
190 visitors, last modified 25 Jan, 2020, URL: