High serum concentration of vitamin D may protect against multiple sclerosis
Multiple Sclerosis Journal – Experimental, Translational and Clinical https://doi.org/10.1177/2055217319892291
Martin Biström, Lucia Alonso-Magdalena, Oluf Andersen, ...
Swedish case-control study compared 670 people who got MS vs 670 who did not get MS
Vitamin D levels were taken about 8 years before the MS
15.5% of those WITH MS previously had >30 ng of vitamin D
20.5% of those WITHOUT MS previously had >30 ng of Vitamin D
- Overview MS and vitamin D
- An opportunity - use Vitamin D to treat Multiple Sclerosis (has been used for 14 years) - Feb 2022
- Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis May 2018
- Multiple Sclerosis: 10 percent fewer relapses for each 10 ng higher level of vitamin D – Meta-analysis April 2020
- Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- Multiple Sclerosis relapses cut in half by 100,000 IU of Vitamin D every 2 weeks– RCT 2019
UV and Sunshine reduces MS risk
- Multiple Sclerosis 2X more likely if low winter UV – June 2018
- Multiple Sclerosis half as likely if get plenty of sunshine (not a news item) – March 2018
Other things also help
- Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT July 2018
- Multiple Sclerosis 40 percent less likely if consume tinned fish (Vitamin D and Omega-3) – Sept 2019
- Resveratrol treats Multiple Sclerosis and other autoimmune diseases – many studies
- Not a single case of multiple sclerosis in 15,000,000 people (plant-based diets)
High Dose Vitamin D and cofactors
- Coimbra protocol using high-dose Vitamin D is safe – April 2022
- The use of high dose Vitamin D (Coimbra Protocol) for multiple sclerosis in Germany – 2019
- Comparing High-dose vitamin D therapies MS and other health problems
Number of MS studies which are also in other categories
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22 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells 14 studies in Vitamin D Receptor - gene which restricts D from getting to the cells 7 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells 21 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS Download the PDF from VitaminDWiki
Background
High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals.Objective
Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent.Methods
Prospectively drawn blood samples from individuals later developing relapsing–remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry.Results
High levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50–0.93).Conclusion
These findings further support a role for vitamin D in MS aetiology.References
- 1. Munger, KL, Levin, LI, Hollis, BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006; 296: 2832–2838.
- 2. Salzer, J, Hallmans, G, Nyström, M, et al. Vitamin D as a protective factor in multiple sclerosis. Neurology 2012; 79: 2140–2145.
- 3. Munger KL, Hongell K, Åivo J, et al. 25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort. Neurology 2017; 89: 1578 LP – 1583.
- 4. Mokry, LE, Ross, S, Ahmad, OS, et al. Vitamin D and risk of multiple sclerosis: a Mendelian randomization study. PLOS Med 2015; 12: e1001866.
- 5. Rhead, B, Bäärnhielm, M, Gianfrancesco, M, et al. Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Neurol Genet 2016; 2: e97.
- 6. Simpson, S, van der Mei, I. Vitamin D deficiency is an etiological factor for MS – commentary. Mult Scler 2019; 25: 641–643.
- 7. Brink, M, Johansson, L, Nygren, E, et al. Vitamin D in individuals before onset of rheumatoid arthritis – relation to vitamin D binding protein and its associated genetic variants. BMC Rheumatol 2018; 2: 26.
- 8. Ramnemark, A, Norberg, M, Pettersson-Kymmer, U, et al. Adequate vitamin D levels in a Swedish population living above latitude 63°N: the 2009 Northern Sweden MONICA study. Int J Circumpolar Health 2015; 74: 27963.
- 9. Snellman, G, Melhus, H, Gedeborg, R, et al. Determining vitamin D status: a comparison between commercially available assays. PLoS One 2010; 5: e11555.
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Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019(Cached) Printer Friendly Follow this page for updates8139 visitors, last modified 11 Jul, 2022, This page is in the following categories (# of items in each category)