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Vitamin D cost-effectively treats Multiple Sclerosis – July 2021

Averting multiple sclerosis long-term societal and healthcare costs: The Value of Treatment (VoT) project

Mult Scler Relat Disord. 2021 Jun 30;54:103107. doi: 10.1016/j.msard.2021.103107 PDf is behind a paywall
Michela Tinelli 1, Maura Pugliatti 2, Andreea Antonovici 3, Bettina Hausmann 3, Kerstin Hellwig 4, Vinciane Quoidbach 5, Per Soelberg Sørensen 6

 Previous conference presentation by similar authors, similar title

VitaminDWiki

Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019

UV and Sunshine reduces MS risk

Other things also help

High Dose Vitamin D and cofactors

Number of MS studies which are also in other categories

  • 20 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells
  • 11 studies in Vitamin D Receptor - gene which restricts D from getting to the cells
  • 7 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells
  • 20 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS
  • 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS

Background and purpose: The recent report on Value-of-Treatment (VoT) project highlights the need for early diagnosis-intervention, integrated, seamless care underpinning timely care pathways and access to best treatments. The VoT-multiple-sclerosis (MS) economic case study analysis aimed to estimate the effectiveness/cost-effectiveness of both early treatment and reducing MS risk factors (e.g. smoking and vitamin D insufficiency).

Methods: A series of decision analytical modellings were developed and applied to estimate the cost-effectiveness of: (1) reducing the conversion from clinically-isolated-syndrome (CIS) to clinically-definite-MS (CDMS); (2) smoking cessation and increase of 25 hydroxyvitamin D (25(OH)D) serum level. Both (1) and (2) considered socioeconomic impact on averted MS disability progression. Costs were reported for societal and healthcare provider perspectives (pending on data across nations; Euros). Effectiveness was expressed as Quality-Adjusted-Life-Years (QALYs) gains. Long term (25, 30, 40,50-years) and short (one-year) timelines were considered for (1) and (2), respectively.

Results: Early treatment was cost-effective for the health care provider and both cost-effective/cost-saving for the society across time-horizons and nations. Smoking cessation and an increase of 25(OH)D in MS patients were both cost-effective/cost-saving across nations.

Conclusions: To the best of our knowledge, our work provides the first economic evidence to base appropriate public health interventions to reduce the MS burden in Europe.

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Created by admin. Last Modification: Tuesday June 28, 2022 21:24:03 GMT-0000 by admin. (Version 8)

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