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Multiple Sclerosis 2X more likely if low winter UV – June 2018

Lifetime exposure to ultraviolet radiation and the risk of multiple sclerosis in the US radiologic technologists cohort study.

Mult Scler. 2018 Jun 1:1352458518783343. doi: 10.1177/1352458518783343. [Epub ahead of print]
Gallagher LG1, Ilango S2, Wundes A3, Stobbe GA3, Turk KW3, Franklin GM4, Linet MS5, Freedman DM5, Alexander BH6, Checkoway H7.


Those (of 40,000) who got MS were 2X more likely to have lived in a region with low wintertime UV

Items in both categories MS and Far From Equator are listed here:

Items in both categories MS and UV are listed here:

 Download the PDF from VitaminDWiki

BACKGROUND: Low exposure to ultraviolet radiation (UVR) from sunlight may be a risk factor for developing multiple sclerosis (MS). Possible pathways may be related to effects on immune system function or vitamin D insufficiency, as UVR plays a role in the production of the active form of vitamin D in the body.

OBJECTIVE: This study examined whether lower levels of residential UVR exposure from sunlight were associated with increased MS risk in a cohort of radiologic technologists.

METHODS: Participants in the third and fourth surveys of the US Radiologic Technologists (USRT) Cohort Study eligible ( N = 39,801) for analysis provided complete residential histories and reported MS diagnoses. MS-specialized neurologists conducted medical record reviews and confirmed 148 cases. Residential locations throughout life were matched to satellite data from NASA's Total Ozone Mapping Spectrometer (TOMS) project to estimate UVR dose.

RESULTS: Findings indicate that MS risk increased as average lifetime levels of UVR exposures in winter decreased. The effects were consistent across age groups <40 years. There was little indication that low exposures during summer or at older ages were related to MS risk.

CONCLUSION: Our findings are consistent with the hypothesis that UVR exposure reduces MS risk and may ultimately suggest prevention strategies.

It appears that latitude has been considered a proxy for winter UVB for a long time

Comparisons of estimated economic burdens due to insufficient solar ultraviolet irradiance and vitamin D and excess solar UV irradiance for the United States.
Photochem Photobiol. 2005 Nov-Dec;81(6):1276-86. DOI: 10.1562/2005-01-24-RA-424
PDF is available free at Sci-Hub
Grant WB1, Garland CF, Holick MF.

  • " Latitude is assumed to be an index of wintertime vitamin D status as determined by serum 25(OH)D levels"
  • " In fact, for children living in Tasmania, Australia (41"-43" S), wintertime exposure to solar UVB radiation was a more important factor than summertime exposure for reducing the adult risk of MS (84)."

Created by admin. Last Modification: Thursday December 19, 2019 22:18:23 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
10005 MS 2X if low winter UVR.jpg admin 23 Jun, 2018 18.51 Kb 594
10004 UVR MS.pdf admin 23 Jun, 2018 91.78 Kb 679