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Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019

High serum concentration of vitamin D may protect against multiple sclerosis

Multiple Sclerosis Journal – Experimental, Translational and Clinical https://doi.org/10.1177/2055217319892291
Martin Biström, Lucia Alonso-Magdalena, Oluf Andersen, ...

VitaminDWiki

Swedish case-control study compared 670 people who got MS vs 670 who did not get MS
Vitamin D levels were taken about 8 years before the MS
15.5% of those WITH MS previously had >30 ng of vitamin D
20.5% of those WITHOUT MS previously had >30 ng of Vitamin D


UV and Sunshine reduces MS risk

Other things also help

High Dose Vitamin D and cofactors

Number of MS studies which are also in other categories

  • 20 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells
  • 11 studies in Vitamin D Receptor - gene which restricts D from getting to the cells
  • 5 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells
  • 19 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS
  • 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS

 Download the PDF from VitaminDWiki

Background
High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals.

Objective
Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent.

Methods
Prospectively drawn blood samples from individuals later developing relapsing–remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry.

Results
High levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50–0.93).

Conclusion
These findings further support a role for vitamin D in MS aetiology.

References

  • 1. Munger, KL, Levin, LI, Hollis, BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006; 296: 2832–2838.
  • 2. Salzer, J, Hallmans, G, Nyström, M, et al. Vitamin D as a protective factor in multiple sclerosis. Neurology 2012; 79: 2140–2145.
  • 3. Munger KL, Hongell K, Åivo J, et al. 25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort. Neurology 2017; 89: 1578 LP – 1583.
  • 4. Mokry, LE, Ross, S, Ahmad, OS, et al. Vitamin D and risk of multiple sclerosis: a Mendelian randomization study. PLOS Med 2015; 12: e1001866.
  • 5. Rhead, B, Bäärnhielm, M, Gianfrancesco, M, et al. Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Neurol Genet 2016; 2: e97.
  • 6. Simpson, S, van der Mei, I. Vitamin D deficiency is an etiological factor for MS – commentary. Mult Scler 2019; 25: 641–643.
  • 7. Brink, M, Johansson, L, Nygren, E, et al. Vitamin D in individuals before onset of rheumatoid arthritis – relation to vitamin D binding protein and its associated genetic variants. BMC Rheumatol 2018; 2: 26.
  • 8. Ramnemark, A, Norberg, M, Pettersson-Kymmer, U, et al. Adequate vitamin D levels in a Swedish population living above latitude 63°N: the 2009 Northern Sweden MONICA study. Int J Circumpolar Health 2015; 74: 27963.
  • 9. Snellman, G, Melhus, H, Gedeborg, R, et al. Determining vitamin D status: a comparison between commercially available assays. PLoS One 2010; 5: e11555.
  • 10. Marklund, M, Wu, JHY, Imamura, F, et al. Biomarkers of dietary omega-6 fatty acids and incident cardiovascular disease and mortality. Circulation 2019; 139: 2422–2436.


Created by admin. Last Modification: Saturday January 25, 2020 12:31:25 GMT-0000 by admin. (Version 10)

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ID Name Comment Uploaded Size Downloads
13105 MS High Vitamin D.pdf PDF 2019 admin 07 Dec, 2019 12:50 401.51 Kb 104
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