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People with Multiple Sclerosis taking at least 5,000 IU of Vitamin D felt much better – April 2021

Self-reported use of vitamin D supplements is associated with higher physical quality of life scores in multiple sclerosis

Mult Scler Relat Disord . 2021 Jan 16;49:102760. doi: 10.1016/j.msard.2021.102760
Steve Simpson-Yap 1, Pia Jelinek 2, Tracey Weiland 3, Nupur Nag 3, Sandra Neate 3, George Jelinek 3


Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019

UV and Sunshine reduces MS risk

Other things also help

High Dose Vitamin D and cofactors

Number of MS studies which are also in other categories

  • 22 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells
  • 12 studies in Vitamin D Receptor - gene which restricts D from getting to the cells
  • 7 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells
  • 21 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS
  • 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS

 Download the PDF from VitaminDWiki

Background: Sun exposure and vitamin D, including intake and serum levels, have been associated with reduced risk of MS onset and less progression and may affect quality of life (QoL). We investigated the prospective relationship of these factors with QoL from baseline to 2.5 years' follow-up, in an international cohort of people with MS.

Methods: Data derive from the HOLISM international cohort. Sun exposure and vitamin D supplement use were queried at both timepoints. QoL was assessed by MSQOL-54, estimating physical and mental health QoL composite scores. Characteristics of QoL were assessed by linear regression, adjusted for age, sex, socioeconomic status, treated comorbidity number, MS type, disability, clinically significant fatigue, prescription antidepressant medication use, and ongoing relapse symptoms, and baseline QoL score, as appropriate, estimating adjusted coefficients (aβ).

Results: At 2.5-year review, QoL scores were higher among those reporting taking vitamin D supplements (physical: aβ=3.58, 95%CI=1.35-5.80; mental: aβ=3.08, 95%CI=0.72-5.44), particularly average daily dose over 5,000IU/d. Baseline-reported vitamin D supplementation was associated with greater increase in physical (aβ=1.02, 95%CI=0.22-1.81), but not mental QoL (aβ=0.11, 95%CI=-1.00-1.23). Sun exposure was cross-sectionally associated with higher QoL scores at follow-up but was not associated with change in QoL.

Conclusions: Self-reported vitamin D supplement use was cross-sectionally associated with higher physical and mental QoL, but prospectively only with increased physical QoL.

Created by admin. Last Modification: Wednesday February 10, 2021 14:30:13 GMT-0000 by admin. (Version 2)

Attached files

ID Name Comment Uploaded Size Downloads
14999 QoL vs vitamin D.jpg admin 06 Feb, 2021 39.90 Kb 277
14998 PIIS2211034821000262.pdf admin 06 Feb, 2021 617.24 Kb 255