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Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015

Vitamin D receptor gene polymorphisms and the risk for female reproductive cancers: A meta-analysis

Maturitas, Volume 81, Issue 2, June 2015, Pages 256–265
Myung-Jin Mun a, b, Tae-Hee Kim c heeobgy at naver.com Ji-Young Hwang d, Won-Cheoul Jang a
a Department of Chemistry, School of Natural Science, Dankook University, Cheonan 330-714, Republic of Korea
b Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea
c Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon 420-767, Republic of Korea
d Department of Biomedical Engineering, Korea University College of Health Science, Seoul 136-713, Republic of Korea

Highlights

  • The FokI polymorphism was related to increased risks for breast and ovarian cancers.
  • The BsmI polymorphism was associated with a decreased risk for developing cancers.
  • We suggest monitoring VDR gene polymorphisms as potential biomarkers.
VitaminDWiki Comment

Folki gene error is again found to be related to increased rates of breast and ovarian cancers
Many other studies have found similar increased risk of a variety of cancers due to genes
The errors slightly reduce the Vitamin D Receptor (VDR)
Unfortunately the effect of VDR modification cannot be detected with vitamin D tests
   The reduction of reception of the vitamin D happens after it has left the bloodstream
However, people with these errors can compensate by taking slightly more vitamin D
See also VitaminDWiki

Pages listed in BOTH Breast Cancer AND Genetics

Pages listed in BOTH Breast Cancer AND Vitamin D Receptor


Vitamin D receptor (VDR) gene polymorphisms and the risks for various breast and ovarian cancers have been reported in many epidemiological studies. However, the associations between VDR gene polymorphisms and the risk for each type of cancer are unclear. The aim of this meta-analysis was to evaluate the associations between VDR gene polymorphisms and female reproductive cancers. A systematic review was performed with the PubMed Science Direct, Scopus, and Google Scholar databases up to April 2014 using the search terms “vitamin D receptor or VDR” and “variant or polymorphism or SNP” with terms for breast, ovarian, cervical, endometrial, uterine, and vaginal cancers. A meta-analysis with the pooled odds ratios and 95% confidence intervals was carried out to assess the associations between VDR polymorphisms (Cdx-2, FokI, BsmI, ApaI, and TaqI) and the risks for reproductive cancers under the heterozygous, homozygous, dominant, and recessive models with fixed or random effects models.
Six ovarian cancer studies (13 individual studies involving 4107 cases and 6661 controls) and 29 breast cancer studies (38 individual studies involving 16,453 cases and 22,044 controls) were included in our meta-analysis.

Our results indicate that the FokI polymorphism was related to increased risks for breast and ovarian cancers, whereas the BsmI polymorphism was associated with a decreased risk for developing these cancers. Our comprehensive meta-analysis indicated that the FokI and BsmI VDR gene polymorphisms may be significantly associated with gynecological cancers. We suggest monitoring VDR gene polymorphisms as potential biomarkers in patients with gynecological malignancy.

Abbreviations: VDR, vitamin D receptor; OR, odds ratio; CI, confidence interval; HWE, Hardy–Weinberg equilibrium

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