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Severe periodontitis is half as likely at 60 ng of vitamin D – Sept 2021

Serum 25-hydroxyvitamin D is negatively associated with severe periodontitis: a cross-sectional study

Fangjing Zhou, Ning Ma, Ruiting Su, Xiaoyu He, Xiaona Wang, Yang Zhou & Jing Shi
BMC Oral Health volume 21, Article number: 479 (2021)

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Omega-3 helped periodontal treatment (details behind paywall) - meta-analysis Dec 2023 21 Dec, 2023
Periodontal Health helped a bit by small amounts of vitamin D for short durations – review of 4 studies Oct 2023 30 Oct, 2023
Chronic Periodontitis reduced by Vitamin D (60,000 IU weekly for 8 weeks) – RCT July 2023 01 Sep, 2023
Periodontal Inflammation in seniors ceases to increase when Vitamin D is higher than 27 ng – Sept 2023 19 Aug, 2023
800 IU vitamin D helped periodontal surgery – May 2011 02 Aug, 2023
Vitamin D and Periodontal Disease – continuing education March 2012 02 Aug, 2023
Periodontal Disease and Vitamin D - interview and transcript - GRH, Grant July 2023 02 Aug, 2023
Periodontitis reduced by Vitamin D - many studies 05 Jun, 2023
Chronic periodontitis associated with low vitamin D and low vitamin B12 – May 2023 02 Jun, 2023
increased Periodontal Disease risk if low Vitamin D, Magnesium, Omega-3 - GRH March 2023 20 Mar, 2023
The worse the Periodontitis, the lower the Vitamin D – April 2022 26 Apr, 2022
Periodontitis problems often 3X more likely if poor Vitamin D receptor – May 2022 07 Apr, 2022
Osteoporosis, periodontal and other diseases share a risk factor – low vitamin D – March 2022 05 Mar, 2022
Periodontitis probably related to low Vitamin D – review June 2018 28 Sep, 2021
Severe periodontitis is half as likely at 60 ng of vitamin D – Sept 2021 28 Sep, 2021
Periodontitis treated by 4,000 IU of Vitamin D (pilot study) - March 2019 27 Mar, 2019
Periodontitis associated with low Vitamin D if dark-skinned – Dec 2018 22 Dec, 2018
Periodontitis with low Vitamin D increases risk of Diabetes by 2.8 X – July 2018 20 Sep, 2018
Chronic Periodontitis reduced by Omega-3 – RCT Sept 2018 08 Sep, 2018
Periodontal diseases are treated by Vitamin D - how much is needed, and when – June 2018 14 Jul, 2018
Poor Periodontal associated with low vitamin D in 65 percent of cross-sectional studies – review March 2018 01 Mar, 2018
Generalized Aggressive Periodontitis is 3X more likely if too much Vitamin D-Binding Protein – Nov 2016 09 Nov, 2017
Periodontal disease 1.5 times more likely if low vitamin D – Sept 2016 09 Oct, 2016
Hypothesis: Periodontal disease is related to vitamin D – 2010 09 Oct, 2016
Chronic Periodontitis 9.6 times more likely if smoke and have poor Vitamin D Receptor – Aug 2016 29 Sep, 2016
Even 1000 IU vitamin D reduced periodontitis – Jan 2011 21 Dec, 2015
Strontium and vitamin D patented in 2008 for periodontitis, gingivitis 29 Aug, 2012
1000 IU helped reduce periodontitis – Sept 2010 11 Aug, 2012

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Background
Periodontitis can lead to the destruction of periodontium and adversely influence the overall health, wellbeing, and quality of life. However, studies on the relationship between severe periodontitis and serum 25-hydroxyvitamin D 25(OH)D are limited. This study is designed to explore the relationship between 25(OH)D and severe periodontitis.

Methods
A cross-section study of 2928 participants enrolled from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2014 was conducted. The periodontal examination was performed using a total oral periodontal examination program, and probe measurements were collected at six sites per tooth in NHANES. Severe periodontitis was characterized as: ≥ 2 interproximal sites with attachment loss (AL) ≥ 6 mm (not on the same tooth) and ≥ 1 interproximal site with probing depth (PD) ≥ 5 mm. Severe periodontitis and serum 25(OH)D were the dependent and independent variables, respectively. Univariate, multivariate, and subgroup analyses were performed to explore the relationship between severe periodontitis and serum 25(OH)D.

Results
Among the 2928 participants, the average age of the population was 50 ± 13.71 years old, with 1425 (48.67%) males, 316 (10.79%) exhibited severe periodontitis. Serum 25(OH)D showed a significantly negative association with severe periodontitis after adjusting all variables (OR 0.75, 95% CI 0.63–0.89). In addition, severe periodontitis has a nonlinear relationship with serum 25(OH)D, whoes inflection point was 102 (nmol/L). On the left side of the inflection point (25(OH)D ≤ 102 nmol/L), the effect size was 0.98 and 95%CI was 0.98–0.99 (25(OH)D per 1 nmol/L increments). On the right side of the inflection point (25(OH)D > 102 nmol/L), the effect size was 0.99 and 95% CI was 0.98–1.01. The subgroup analysis showed pronounced changes in non-Hispanic white, alcohol consumption, diabetes, and health insurance.

Conclusion
Serum 25 (OH) D in relation to severe periodontitis is nonlinear in our study.When serum 25 (OH) D is less than 102 nmol/L, serum


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