Journal of Periodontal Research, 2018, https://doi.org/10.1111/jre.12560
M. Perić - Cliniques Universitaires Saint-Luc
E. Cavalier - Department of Clinical Chemistry, CHU Sart‐Tilman, University of Liège, Liège, Belgium
S. Toma - Cliniques Universitaires Saint-Luc
It might be that periodontitis, like several other health problems, is more associated with Vitamin D related genes than Vitamin D in the blood. The genes can restrict a good level if Vitamin D in the blood from actually getting to the cells
Dental category listing has
- Generalized Aggressive Periodontitis is 3X more likely if too much Vitamin D-Binding Protein – Nov 2016
- Periodontitis associated with low Vitamin D if dark-skinned – Dec 2018
- Periodontitis treated by 4,000 IU of Vitamin D (pilot study) - March 2019
- 1.8 X more likely to have additional Dental Implant Failure if poor Vitamin D Receptor – Dec 2019
- Early tooth decay 1.9 X more likely if a poor Vitamin D receptor – July 2017
- Chronic Periodontitis 9.6 times more likely if smoke and have poor Vitamin D Receptor – Aug 2016
- Dental carries associated with poor vitamin D receptor (TaqI genotypes) – 2016
The aim of this systematic review was to explore the relationship between serum vitamin D levels and periodontal disease. The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The focused PICO question was: Are serum vitamin D levels (I) associated with gingivitis or periodontitis (C) in healthy humans (P)? PubMed (Medline), Embase, Science Direct, the Cochrane library, and grey literature were searched up to 31 July 2017. Two reviewers independently selected studies and extracted data. Quality, risk of bias, and heterogeneity of the studies were assessed using the Newcastle-Ottawa Scale. In total, 365 studies were identified and 24 were analyzed.
Seven studies fulfilled the inclusion criteria.
- Four case-control studies showed an influence of vitamin D and its metabolites on periodontal health status/disease.
- One interventional study suggested the proposed anti-inflammatory role of vitamin D.
- Two cross-sectional studies failed to show a relationship between vitamin D and periodontal condition.
The literature on the effect of serum vitamin D levels on periodontal status remains scarce and controversial. Some data, however, support a "perio-protective" role for vitamin D. There is a need for well-designed randomized clinical trials to explore the possible anti-inflammatory effect of vitamin D on periodontal health.
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