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Chronic Periodontitis reduced by Vitamin D (60,000 IU weekly for 8 weeks) – RCT July 2023

Assessment of Outcome of Oral Supplementation of Vitamin D3 as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients with Type II Diabetes Mellitus – A Randomized Controlled Clinical Trial

J. of Pharmacy and Bioallied Sciences 15(Suppl 1):p S346-S349, July 2023. DOI: 10.4103/jpbs.jpbs_543_22
Ramaprabha, G1; Khan, Nubesh S.2; Kunusoth, Ramesh3; Kakati, Indrajit4; Hussain Qadri, Syed Shah5; Seshadri, Pavithra Rangarajan6

Both diabetes and periodontitis affect millions of people worldwide and Vitamin D insufficiency may create a conducive environment for the progression of diabetes and periodontal disease. The aim of the study was to assess the outcome of oral supplementation of Vitamin D3 in patients with Type 2Diabetes Mellitus with generalized chronic periodontitis, as an adjuvant toscaling and root planing.

A total of 92 patients, including 46 each in non-diabetic and diabetec group. Clinical parameters including Plaque Index (PI), Gingival Bleeding Index (GBI), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), levels of Vitamin D in serum, and Fasting Blood sugar were assessed at the baseline. SRP was finished for each participant in the trial. Following SRP, the first 25 people in each group got 60,000 IU of oral vitamin D3 granules once a week for eight weeks, while the remaining 21 subjects from each group did not. At the conclusion of the 8th week following interventions, all the indicators were reviewed.

Following SRP and Vitamin D supplementation there was a measurably critical reduction in every one of the periodontal clinical indicators in both groups. In both groups, there was a statistically significant rise in serum vitamin D levels.

In addition to SRP, vitamin D supplementation shows promise as a host immunomodulatory drug in the management of periodontitis, particularly in patients with diabetes mellitus.
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Items found: 28
Title Modified
Omega-3 helped periodontal treatment (details behind paywall) - meta-analysis Dec 2023 21 Dec, 2023
Periodontal Health helped a bit by small amounts of vitamin D for short durations – review of 4 studies Oct 2023 30 Oct, 2023
Chronic Periodontitis reduced by Vitamin D (60,000 IU weekly for 8 weeks) – RCT July 2023 01 Sep, 2023
Periodontal Inflammation in seniors ceases to increase when Vitamin D is higher than 27 ng – Sept 2023 19 Aug, 2023
800 IU vitamin D helped periodontal surgery – May 2011 02 Aug, 2023
Vitamin D and Periodontal Disease – continuing education March 2012 02 Aug, 2023
Periodontal Disease and Vitamin D - interview and transcript - GRH, Grant July 2023 02 Aug, 2023
Periodontitis reduced by Vitamin D - many studies 05 Jun, 2023
Chronic periodontitis associated with low vitamin D and low vitamin B12 – May 2023 02 Jun, 2023
increased Periodontal Disease risk if low Vitamin D, Magnesium, Omega-3 - GRH March 2023 20 Mar, 2023
The worse the Periodontitis, the lower the Vitamin D – April 2022 26 Apr, 2022
Periodontitis problems often 3X more likely if poor Vitamin D receptor – May 2022 07 Apr, 2022
Osteoporosis, periodontal and other diseases share a risk factor – low vitamin D – March 2022 05 Mar, 2022
Periodontitis probably related to low Vitamin D – review June 2018 28 Sep, 2021
Severe periodontitis is half as likely at 60 ng of vitamin D – Sept 2021 28 Sep, 2021
Periodontitis treated by 4,000 IU of Vitamin D (pilot study) - March 2019 27 Mar, 2019
Periodontitis associated with low Vitamin D if dark-skinned – Dec 2018 22 Dec, 2018
Periodontitis with low Vitamin D increases risk of Diabetes by 2.8 X – July 2018 20 Sep, 2018
Chronic Periodontitis reduced by Omega-3 – RCT Sept 2018 08 Sep, 2018
Periodontal diseases are treated by Vitamin D - how much is needed, and when – June 2018 14 Jul, 2018
Poor Periodontal associated with low vitamin D in 65 percent of cross-sectional studies – review March 2018 01 Mar, 2018
Generalized Aggressive Periodontitis is 3X more likely if too much Vitamin D-Binding Protein – Nov 2016 09 Nov, 2017
Periodontal disease 1.5 times more likely if low vitamin D – Sept 2016 09 Oct, 2016
Hypothesis: Periodontal disease is related to vitamin D – 2010 09 Oct, 2016
Chronic Periodontitis 9.6 times more likely if smoke and have poor Vitamin D Receptor – Aug 2016 29 Sep, 2016
Even 1000 IU vitamin D reduced periodontitis – Jan 2011 21 Dec, 2015
Strontium and vitamin D patented in 2008 for periodontitis, gingivitis 29 Aug, 2012
1000 IU helped reduce periodontitis – Sept 2010 11 Aug, 2012

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