Periodontitis treated by 4,000 IU of Vitamin D (pilot study) - March 2019

The Influence of Vitamin D Supplementation on Local and Systemic Inflammatory Markers in Periodontitis Patients: A Pilot Study.

Oral Dis. 2019 Mar 26. doi: 10.1111/odi.13097
Meghil MM1,2, Hutchens L1, Raed A3, Multani NA4, Rajendran M1, Zhu H3, Looney S5, Elashiry M1,2, Arce RM1, Peacock ME1, Dong Y3, Cutler CW1.

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OBJECTIVES:
Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation on mediators of systemic inflammation in dark-skinned, periodontitis patients.

MATERIALS AND METHODS:
A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or Placebo group and received intensive single visit scaling and root planing to elicit a systemic inflammatory response.

RESULTS:
Vitamin D supplementation (VDS) increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs.

CONCLUSION:
In conclusion, vitamin D supplementation has multiple benefits for reducing systemic inflammation and promoting induction of autophagy related proteins related to anti-microbial functions.