- A Randomized Controlled Trial on Safety and Efficacy of Single Intramuscular versus Staggered Oral Dose of 600 000IU Vitamin D in Treatment of Nutritional Rickets
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2 studies in both categories Rickets and Injection
A Randomized Controlled Trial on Safety and Efficacy of Single Intramuscular versus Staggered Oral Dose of 600 000IU Vitamin D in Treatment of Nutritional Rickets
J Trop Pediatr (2014) doi: 10.1093/tropej/fmt105
Krishanu Mondal 1, Anju Seth 1, <anjuseth.peds@gmail.com>, Raman K. Marwaha 2, Dinesh Dhanwal 3, Satinder Aneja 1, Ritu Singh 4 and Pitambar Sonkar 5
1Department of Paediatrics, Lady Hardinge Medical College, Kalawati Saran Children’s Hospital, New Delhi, DL 110001, India
2Department of Endocrinology, Institute of Nuclear Medicine and Allied Sciences, New Delhi, DL 110001, India
3Department of Medicine, Maulana Azad Medical College, New Delhi, DL 110001, India
4Department of Biochemistry, Lady Hardinge Medical College, New Delhi, DL 110001, India
5Department of Radiology, Lady Hardinge Medical College, Kalawati Saran Children’s Hospital, New Delhi, DL 110001, IndiaObjective: Comparison of efficacy and safety of two different regimens of vitamin D—600 000 IU as a single intramuscular dose, and 60 000IU orally once a week for 10 weeks—in treatment of nutritional rickets.
Methods: Children with nutritional rickets (age: 0.5–5 years, n = 61) were randomized to receive either 60 000IU vitamin D orally once a week for 10 weeks or 600 000IU single intramuscular injection. Serum calcium, phosphate, alkaline phosphatase, urinary calcium/creatinine ratio, serum 25 hydroxy vitamin D and radiological score were compared at 12-week follow-up.
Results: No difference was found in efficacy of the two regimens on comparing biochemical and radiological parameters. Serum 25 hydroxy vitamin D >100 ng/ml was found in two children in the oral group and one child in the intramuscular group. No child developed hypercalcemia or hypercalciuria after starting treatment.
Conclusion: Staggered oral and one-time intramuscular administrations of 600 000IU vitamin D are equally effective and safe in treatment of nutritional rickets.
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67 items in Vitamin D Injection category - Vitamin D injections last longer (3 month vs 2 month) than loading doses
- Getting Vitamin D into your blood and cells shows the many ways of getting Vitamin D
- Injections are currently made by medical professionals into muscle
- Home injection of Vitamin D appears to be possible in the future
- Injections are useful for people who might forget to take their periodic supplement (children, elderly, etc) and those who cannot swallow or have poor digestion
- While Vitamin D2 is historically the common form, Vitamin D3 is far better
- Should check (if there is time) for possible allergic reaction to Vitamin D or lack of Magnesium for both for loading dose and injection
- Note 600,000 IU Vitamin D loading dose via capsules is 1/20th the cost($2.40) of an injection, and does not require a prescription
- 100,000 IU single dose of vitamin D - 2010 has the following
- Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017 has the following
- Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies might include injection
VitaminDWiki -
2 studies in both categories Rickets and Injection This list is automatically updated
Rickets prevented by single injection of vitamin D or weekly supplementation – RCT Jan 20145210 visitors, last modified 31 Jan, 2025, This page is in the following categories (# of items in each category)Attached files
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