Glob Pediatr Health. 2017 Jun 1;4:2333794X17711342. doi: 10.1177/2333794X17711342. eCollection 2017.
Itoh M1, Tomio J1, Toyokawa S1, Tamura M1, Isojima T1, Kitanaka S1, Kobayashi Y1.
1 The University of Tokyo, Tokyo, Japan.
- Overview of Rickets and Vitamin D
- Rickets in UK increased 4X in a decade - May 2015
- Vitamin D and Rickets consensus took 80 years – how long till consensuses on 30 other health problems – Feb 2016
- Rickets needs Vitamin D and Calcium - Global Consensus Jan 2016
- Infant positional skull deformation 7X more frequent if less than 400 IU of vitamin D – Nov 2014
- Rickets reduced 60X - lessons learned by Turkey 2011
Objectives: Our study aimed to clarify the trend of vitamin D deficiency and rickets diagnosed in the past 10 years.
Methods: This observational study used health insurance claims data from 2005 to 2014. The number of beneficiaries for 2005 and 2014 were 91 617 and 365 800, respectively. We included children aged 0 to 15 years diagnosed with vitamin D deficiency or vitamin D-deficient rickets; those with congenital/secondary rickets and low-birth-weight infants were excluded. We analyzed the number of patients and the temporal trend of these diseases in Japan.
Results: The annual number of patients from 2005 to 2008 was <5. The number of patients in 2009 and 2014 were 3.88 (95% confidence interval = 1.77-7.37) and 12.30/100 000 (95% confidence interval = 8.97-16.46), respectively.
Conclusions: Diagnosed cases of vitamin D deficiency and vitamin D-deficient rickets have apparently increased in Japan. Further studies to identify the trend, cause, and prevention of vitamin D-deficient rickets are necessary.
PMID: 28607944 PMCID: PMC5456026 DOI: 10.1177/2333794X17711342