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Omega-3 may reduce weight gain and maintain weight loss – Aug 2018

Omega-3 fatty acids in obesity and metabolic syndrome: a mechanistic update

The Journal of Nutritional Biochemistry, Vol 58, August 2018, Pages 1-16, https://doi.org/10.1016/j.jnutbio.2018.02.012
Kembra Albracht-Schulte a,b, Nishan Sudheera Kalupahanaa,b,d,⁎, Latha Ramalingama,b, Shu Wang a,b,
Shaikh Mizanoor Rahman a,b, Jacalyn Robert-McComb b, c, Naima Moustaid-Moussa a,b, naima.moustaid-moussa at ttu.edu
a Department of Nutritional Sciences, Texas Tech University, Lubbock, TX, USA
b Obesity Research Cluster, Texas Tech University, Lubbock, TX, USA
c Department of Kinesiology, Texas Tech University, Lubbock, TX, USA
d Department of Physiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka

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236 Omega-3 items in category

Omega-3 and Vitamin D separately and together help with Depression, Cardiovascular, Cognition, Pregnancy, Infant, Obesity, Mortality, Breast Cancer, Surgery, and Inflammation
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Strategies to reduce obesity have become public health priorities as the prevalence of obesity has risen in the United States and around the world. While the anti-inflammatory and hypotriglyceridemic properties of long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs) are well known, their antiobesity effects and efficacy against metabolic syndrome, especially in humans, are still under debate. In animal models, evidence consistently suggests a role for n-3 PUFAs in reducing fat mass, particularly in the retroperitoneal and epididymal regions.
In humans, however, published research suggests that though n-3 PUFAs may not aid weight loss, they may attenuate further weight gain and could be useful in the diet or as a supplement to help maintain weight loss. Proposed mechanisms by which n-3 PUFAs may work to improve body composition and counteract obesity-related metabolic changes include modulating lipid metabolism; regulating adipokines, such as adiponectin and leptin; alleviating adipose tissue inflammation; promoting adipogenesis and altering epigenetic mechanisms.

Conclusions from PDF
The management of obesity has shifted from a narrow focus on BMI to the wider field that includes the complications of obesity, with the goal to reduce obesity-associated comorbidities [209]. While n-3 PUFAs have not yet shown consistent benefits in terms of weight loss in humans, improvements in the metabolic profile of obese individuals have been demonstrated.
Therefore, n-3 PUFAs may be an important adjunct to obesity management along with lifestyle modification and pharmacotherapy.
Further study of the genetic and epigenetic molecular targets related to metabolism, appetite and energetics could aid the discovery of novel therapeutic targets for obesityassociated metabolic disorders.

Created by admin. Last Modification: Saturday November 3, 2018 15:06:06 UTC by admin. (Version 6)

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