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Omega-3 index replaces the Omega-6 to Omega-3 ratio – March 2018

The Omega-6:Omega-3 ratio: A critical appraisal and possible successor

Prostaglandins, Leukotrienes and Essential Fatty Acids, 20 March 2018, https://doi.org/10.1016/j.plefa.2018.03.003
William S.Harris


  • Polyunsaturated fatty acid blood levels have predictive power for disease outcomes.
  • Both the Omega-3 Index and the n6:n3 ratio have been used to express PUFA status.
  • The n6:n3 ratio has become scientifically out-dated.
  • The Omega-3 Index, because if included EPA and DHA only, is a preferred metric.

The well-known health effects of the long-chain, marine omega-3 (n-3) fatty acids (FAs) has led to a growing interest in the prognostic value that blood levels of these FAs might have vis-à-vis cardiovascular and neurocognitive diseases. The measurement and expression of n-3 FA levels is not straight-forward, however, and a wide variety of means of expression of n-3 FA status have been used in research and clinical medicine. This has led to considerable confusion as to what “optimal” n-3 FA status is. The n-6:n-3 ratio has enjoyed relatively widespread use, but this apparently simple metric has both theoretical and practical difficulties that have contributed to misunderstandings in this field. Just as the once-popular polyunsaturated:saturated FA ratio has largely disappeared from the nutritional and medical literature, it may be time to replace the n-6:n-3 ratio with a newer metric that focuses on the primary deficiency in Western diets – the lack of eicosapentaenoic and docosahexaenoic acids (EPA and DHA). The Omega-3 Index (red blood cell EPA+DHA) has much to recommend it in this regard.

 Download the PDF from Sci-Hub via VitaminDWiki

Note: Omega-3 Index cannot get very high (>7) if there is too much Omega-6
Note: Current target for Omega-3 = 8. Japan considers target= 10

Vitamin D and Omega-3 category starts with

374 Omega-3 items in category Omega-3 helps with: Autism (9 studies), Depression (29 studies), Cardiovascular (31 studies), Cognition (48 studies), Pregnancy (39 studies), Infant (26 studies), Obesity (13 studies), Mortality (5 studies), Breast Cancer (6 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc

   See also - Overview: Omega-3 many benefits include helping vitamin D

Created by admin. Last Modification: Saturday June 5, 2021 12:44:06 GMT-0000 by admin. (Version 7)

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9708 O-3 Index vs ratio.jpg admin 16 Apr, 2018 01:32 17.32 Kb 914
9707 Omega-3 Index.pdf PDF 2018 admin 16 Apr, 2018 01:31 938.96 Kb 447
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