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Omega-3 index replaces the Omega-6 to Omega-3 ratio – March 2018

The Omega-6:Omega-3 ratio: A critical appraisal and possible successor

Prostaglandins, Leukotrienes and Essential Fatty Acids, 20 March 2018, https://doi.org/10.1016/j.plefa.2018.03.003
William S.Harris


  • Polyunsaturated fatty acid blood levels have predictive power for disease outcomes.
  • Both the Omega-3 Index and the n6:n3 ratio have been used to express PUFA status.
  • The n6:n3 ratio has become scientifically out-dated.
  • The Omega-3 Index, because if included EPA and DHA only, is a preferred metric.

The well-known health effects of the long-chain, marine omega-3 (n-3) fatty acids (FAs) has led to a growing interest in the prognostic value that blood levels of these FAs might have vis-à-vis cardiovascular and neurocognitive diseases. The measurement and expression of n-3 FA levels is not straight-forward, however, and a wide variety of means of expression of n-3 FA status have been used in research and clinical medicine. This has led to considerable confusion as to what “optimal” n-3 FA status is. The n-6:n-3 ratio has enjoyed relatively widespread use, but this apparently simple metric has both theoretical and practical difficulties that have contributed to misunderstandings in this field. Just as the once-popular polyunsaturated:saturated FA ratio has largely disappeared from the nutritional and medical literature, it may be time to replace the n-6:n-3 ratio with a newer metric that focuses on the primary deficiency in Western diets – the lack of eicosapentaenoic and docosahexaenoic acids (EPA and DHA). The Omega-3 Index (red blood cell EPA+DHA) has much to recommend it in this regard.

 Download the PDF from Sci-Hub via VitaminDWiki

Note: Omega-3 Index can cannot get very high (>7) if there is too much Omega-6
Note: Current target for Omega-3 = 8. Japan considers target= 10

Vitamin D and Omega-3 category starts with

332 Omega-3 items in category

Omega-3 and Vitamin D separately & together help with Autism, Depression, Cardiovascular, Cognition, Pregnancy, Infant, Obesity, Mortality, Breast Cancer, Smoking, Sleep, Stroke, Surgery, Longevity, Trauma, Inflammation, MS, etc
   See also - Overview: Omega-3 many benefits include helping vitamin D

Created by admin. Last Modification: Friday October 25, 2019 13:42:53 GMT-0000 by admin. (Version 5)

Attached files

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9708 O-3 Index vs ratio.jpg admin 16 Apr, 2018 01:32 17.32 Kb 406
9707 Omega-3 Index.pdf PDF 2018 admin 16 Apr, 2018 01:31 938.96 Kb 277
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