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Diabetics with low vitamin D had more cognitive impairment– Aug 2013

Serum levels of 25-hydroxyvitamin D are associated with cognitive impairment in type 2 diabetic adults - 2013

Endocrine. 2013 Aug 28.
Chen RH, Zhao XH, Gu Z, Gu PL, Zhou B, Zhu ZH, Xu LY, Zou YF, Jiang XZ.
Department of Endocrinology, Shanghai Pudong New Area People's Hospital, No.490, South Chuanhuan Road, Shanghai, China.

Hypovitaminosis D is highly prevalent in type 2 diabetes. The aim of this study is to determine the serum levels of 25-hydroxyvitamin D [25(OH)D] in type 2 diabetic patients with and without mild cognitive impairment (MCI), and examine the relationship of 25(OH)D and MCI with other clinical factors.

One hundred and sixty-five diabetic patients were enrolled in this study.
Among whom, 95 patients were considered as MCI [Montreal Cognitive Assessment score (MoCA) < 26] and the other 70 as no MCI (MoCA ≥ 26).

Subjects were assessed clinically. Diabetic patients with MCI had a

  • longer duration of DM,
  • fewer years of education,
  • elevated fasting blood glucose (FBG),
  • resistant index (RI) of carotid, and
  • lower levels of 25(OH)D {[17.35 (13.02-25.92) vs 28.00 (19.67-34.30)] ng/ml, P < 0.001}.

The MoCA score was positively correlated with

  • log10[25(OH)D],
  • education year, and

inversely correlated with

  • duration of DM,
  • history of hypertension,
  • intima-media thickness (IMT),
  • FBG,
  • max-RI, and
  • min-RI.

Log10[25(OH)D] was positively correlated with MoCA score, and inversely correlated with IMT, in multivariate regression analysis adjusted for age, sex, and education year, 25(OH)D (β = 0.210, P = 0.003), history of hypertension (β = -0.191, P = 0.007), IMT (β = -0.194, P = 0.007), and FBG (β = -0.157, P = 0.026) independently predicted MoCA score.

In conclusion, our results suggest that levels of serum 25(OH)D are inversely associated with the cognitive impairment in diabetic patients.
Vitamin D may be a potential protective factor for cognitive impairment in patients with type 2 diabetes.

PMID: 23982512


Increased sugar level increased risk of Cognitive Decline - Feb 2018

__High Blood Sugar Levels Tied to Memory Decline NYT Feb 2018

  • "The study controlled for many other variables, among them age, sex, cholesterol, B.M.I., education, marital status, depression, smoking, alcohol consumption, hypertension and cardiovascular disease."
     Download the study PDF from VitaminDWiki

See also VitaminDWiki

Diseases which are related due to vitamin D deficiency which contains the following list

Some of the disease associations: Disease 1 ==> Disease 2 (both associated with low vitamin D

Attached files

ID Name Comment Uploaded Size Downloads
9339 HbA1c, diabetes and cognitive decline.pdf PDF 2017 admin 12 Feb, 2018 20:35 776.39 Kb 52
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