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Cystic Fibrosis

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See also VitaminDWiki

Breathing category listing has 397 items along with related searches

Inhaled Vitamin D looks like a possibility for CF
COPD Overview


See also web

  • Vitamin D supplementation in patients with cystic fibrosis:
    • A systematic review and meta-analysis - Dec 2020  PDF
    • Mortality. 2 trials studed CF deaths in the 12-month follow-up: 1 intervention, 5 placebo; p=0.03
    • Meta-analysis said Vitamin D did not consistently help - mainly because trials had different outcome measures (other than death)
  • Costly Vertex Drug Is Denied, and Medicaid Patients Sue July 2014
    • Kalydeco, for cystic fibrosis costs $300,000 per year;
    • average lung function improvement of 10.1% after about 11 months, compared with a decline of 0.4% in patients taking placebo….”
    • Note by VitaminDWiki - Vitamin D appears to provide a much better improvement and is 30,000 X less expensive
  • CF trial to use 250,000 IU bolus dose of vitamin D July 2017
    To be followed by maintenance dose of 50,000 IU Vitamin D every 2 weeks
     Download the PDF from VitaminDWiki
  • Patient Voices: Cystic Fibrosis New York Times Oct 2017
    Four CF youths are profiled
    Two are running, one is surfing,
    One stays indoors and takes 50 pills per day
    Another hint that Vitamin D helps (not mentioned by the article)

See also PubMed

See also WikiPedia

  • Cystic fibrosis (CF), also known as mucoviscidosis, is a genetic disorder that affects mostly the lungs but also the pancreas, liver, kidneys and intestine.[1][2] Long-term issues include difficulty breathing and coughing up sputum as a result of frequent lung infections.
  • Other symptoms include sinus infections, poor growth, fatty stool, clubbing of the finger and toes, and infertility in males among others.
  • Different people may have different degrees of symptoms.
  • Occurance: 1 in 30,000 in US, 1 in 1,300 in Ireland
  • Primarily genetic, incureable
  • Congenitally unable to process Vitamin K very well - wonder if vitamin K injections would help
  • "While infants born with it 70 years ago would have been unlikely to live beyond their first year, infants today are likely to live well into adulthood"
  • "Many people with CF are on one or more antibiotics at all times, . . . "

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UK Cystic Fibrosis recommendations to be released in 2017

 Download the UK NHS 2014 draft guidelines of Cystic Fibrosis from VitaminDWiki
 Download the Comments on NHS guidelines - see page 16 for Vitamin D and CF from VitaminDWiki
It is interesting to note that the comments document is 2X larger than the draft document

2014 PHD dissertation on CF and Vitamin D

97 pages by Pincikova
 Download the PDF from VitaminDWiki


Average annual cost of CF $16,000

Understanding the costs of care for cystic fibrosis: an analysis by age and health state March 2013
US $ Costs for patients with mild =$10,151, moderate, =$25,647 and severe =$33,691
Costs: hospital inpatients (58%), followed by pharmaceuticals (29%)
 Download the PDF from VitaminDWiki
_"Cure" for Cystic Fibrosis - Trikafta - Costs $311,000 for a year
Washington Post Oct 2019 a tripple drug
improves lung function by about only 14%
unknonw how many years it needs to be take


Role of vitamin D on gut microbiota in cystic fibrosis - 2018

Journal of Steroid Biochemistry – Jan 2018 Pages 82-87
Mansi Kanhere, Benoit Chassaing, Andrew T. Gewirtz, Vin Tangpricha
Highlights

  • Vitamin D plays a vital role in maintaining the integrity of the gut epithelium.
  • The mechanism underlying this association involves the reduction of pro-inflammatory cytokines such as IL-8 and inhibition of inflammation-induced apoptosis of intestinal epithelial cells by vitamin D.
  • Intestinal dysbiosis is prevalent in CF owing to multiple factors including malabsorption of nutrients and recurrent antibiotics.
  • VDR regulates the composition and functions of the gut microbiota and decreased expression of intestinal epithelial VDR disrupts microbial homeostasis.
  • Vitamin D could be a potential treatment option for altering dysbiosis in CF, but additional trials are needed to evaluate this.

 Download the PDF from VitaminDWiki


CF results in pancreatic insufficiency-induced malabsorption - which reduces the response to standard Vitamin D - Jan 2021

Factors Contributing to Vitamin D Status at Hospital Admission for Pulmonary Exacerbation in Adults With Cystic Fibrosis
Am J Med Sci . 2021 Jan;361(1):75-82. doi: 10.1016/j.amjms.2020.08.020
Should consider gut-friendly forms of Vitamin D, such as nanoemulsions which can be absorbed in the mouth, rather than the gut

Cystic Fibrosis        
37543 visitors, last modified 29 Jan, 2021,
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Attached files

ID Name Comment Uploaded Size Downloads
14737 Cystic FIbrosis Meta-analysis.pdf PDF 2020 admin 19 Dec, 2020 18:09 1.12 Mb 101
10388 59351-159663-1-PB.pdf admin 21 Aug, 2018 14:17 808.63 Kb 576
8933 Role-of-vitamin-D-on-gut-microbiota_2018_The-Journal-of-Steroid-Biochemistry.pdf admin 14 Dec, 2017 00:14 741.29 Kb 882
7989 CF trial 250,000.pdf PDF 2017 admin 15 May, 2017 14:47 432.31 Kb 972
7911 CF costs.pdf PDF admin 10 Apr, 2017 23:20 449.15 Kb 1272
7910 CF Wikipedia.jpg admin 10 Apr, 2017 22:55 89.61 Kb 3151
7887 Vitamin D CF PHD 2014 Pincikova.pdf PDF 2014 admin 04 Apr, 2017 16:30 6.18 Mb 2258
7536 CF lungs.jpg admin 20 Dec, 2016 03:01 62.55 Kb 19597
5194 CF UK draft 2014 comments.pdf admin 18 Mar, 2015 16:24 426.40 Kb 2022
5192 CF UK draft 2014.pdf admin 18 Mar, 2015 16:22 178.59 Kb 2338
5185 CF Wikipedia.jpg admin 17 Mar, 2015 14:32 47.10 Kb 5237
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