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Cystic Fibrosis

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Breathing category listing has 382 items along with related searches

Inhaled Vitamin D looks like a possibility for CF
COPD Overview

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  • Cystic fibrosis (CF), also known as mucoviscidosis, is a genetic disorder that affects mostly the lungs but also the pancreas, liver, kidneys and intestine.[1][2] Long-term issues include difficulty breathing and coughing up sputum as a result of frequent lung infections.
  • Other symptoms include sinus infections, poor growth, fatty stool, clubbing of the finger and toes, and infertility in males among others.
  • Different people may have different degrees of symptoms.
  • Occurance: 1 in 30,000 in US, 1 in 1,300 in Ireland
  • Primarily genetic, incureable
  • Congenitally unable to process Vitamin K very well - wonder if vitamin K injections would help
  • "While infants born with it 70 years ago would have been unlikely to live beyond their first year, infants today are likely to live well into adulthood"
  • "Many people with CF are on one or more antibiotics at all times, . . . "


UK Cystic Fibrosis recommendations to be released in 2017

 Download the UK NHS 2014 draft guidelines of Cystic Fibrosis from VitaminDWiki
 Download the Comments on NHS guidelines - see page 16 for Vitamin D and CF from VitaminDWiki
It is interesting to note that the comments document is 2X larger than the draft document

2014 PHD dissertation on CF and Vitamin D

97 pages by Pincikova
 Download the PDF from VitaminDWiki

Average annual cost of CF $16,000

Understanding the costs of care for cystic fibrosis: an analysis by age and health state March 2013
US $ Costs for patients with mild =$10,151, moderate, =$25,647 and severe =$33,691
Costs: hospital inpatients (58%), followed by pharmaceuticals (29%)
 Download the PDF from VitaminDWiki
_"Cure" for Cystic Fibrosis - Trikafta - Costs $311,000 for a year
Washington Post Oct 2019 a tripple drug
improves lung function by about only 14%
unknonw how many years it needs to be take

Role of vitamin D on gut microbiota in cystic fibrosis - 2018

Journal of Steroid Biochemistry – Jan 2018 Pages 82-87
Mansi Kanhere, Benoit Chassaing, Andrew T. Gewirtz, Vin Tangpricha

  • Vitamin D plays a vital role in maintaining the integrity of the gut epithelium.
  • The mechanism underlying this association involves the reduction of pro-inflammatory cytokines such as IL-8 and inhibition of inflammation-induced apoptosis of intestinal epithelial cells by vitamin D.
  • Intestinal dysbiosis is prevalent in CF owing to multiple factors including malabsorption of nutrients and recurrent antibiotics.
  • VDR regulates the composition and functions of the gut microbiota and decreased expression of intestinal epithelial VDR disrupts microbial homeostasis.
  • Vitamin D could be a potential treatment option for altering dysbiosis in CF, but additional trials are needed to evaluate this.

 Download the PDF from VitaminDWiki

Cystic Fibrosis        
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Attached files

ID Name Comment Uploaded Size Downloads
10388 59351-159663-1-PB.pdf admin 21 Aug, 2018 14:17 808.63 Kb 429
8933 Role-of-vitamin-D-on-gut-microbiota_2018_The-Journal-of-Steroid-Biochemistry.pdf admin 14 Dec, 2017 00:14 741.29 Kb 699
7989 CF trial 250,000.pdf PDF 2017 admin 15 May, 2017 14:47 432.31 Kb 852
7911 CF costs.pdf PDF admin 10 Apr, 2017 23:20 449.15 Kb 1020
7910 CF Wikipedia.jpg admin 10 Apr, 2017 22:55 89.61 Kb 2881
7887 Vitamin D CF PHD 2014 Pincikova.pdf PDF 2014 admin 04 Apr, 2017 16:30 6.18 Mb 2062
7536 CF lungs.jpg admin 20 Dec, 2016 03:01 62.55 Kb 17138
5194 CF UK draft 2014 comments.pdf admin 18 Mar, 2015 16:24 426.40 Kb 1886
5192 CF UK draft 2014.pdf admin 18 Mar, 2015 16:22 178.59 Kb 2204
5185 CF Wikipedia.jpg admin 17 Mar, 2015 14:32 47.10 Kb 4859
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