Single dose (up to 60,000 IU) vitamin D raised levels in 87 percent of Cystic fibrosis patients – RCT March 2013

Single high-dose oral vitamin D3 (stoss) therapy--a solution to vitamin D deficiency in children with cystic fibrosis?

J Cyst Fibros. 2013 Mar;12(2):177-82. doi: 10.1016/j.jcf.2012.08.007. Epub 2012 Sep 19.
Shepherd D1, Belessis Y2, Katz T2, Morton J2, Field P2, Jaffe A2.

OBJECTIVES:
To determine the safety and efficacy of stoss therapy on vitamin D levels over a 12 month period in children with cystic fibrosis and vitamin D deficiency (<75 nmol/L).

STUDY DESIGN:
Retrospective chart review of 142 paediatric CF patients from 2007 till 2011.

RESULTS:
Thirty eight children received stoss therapy and 37 children with vitamin D deficiency were not treated and served as a control group. The stoss treated group had a significant and sustained increase in 25-hydroxyvitamin D levels measured at 1, 3, 6 and 12 months post treatment compared to controls (94.82 ± 41.0 nmol/L, p=0.001; 81.54 ± 24.6 nmol/L, p=0.001; 92.18 ± 36.5 nmol/L, p=0.008 and 64.6 ± 20.0 nmol/L, p=0.006 respectively). At 12 months post intervention, the mean difference in vitamin D levels from baseline between the stoss treated group and controls was significant at 15 nmol/L compared to 5 nmol/L (p=0.038).

CONCLUSION:
Stoss therapy effectively achieves and maintains levels of 25-hydroxyvitamin D greater than 75 nmol/L over 12 months.

PMID: 22998937
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Stoss therapy (Table 1)

25-Hydroxyvitamin D level (nmol/L)	<3 years	3–12 years	>12 years
≤25	200 000 IU	400 000 IU	600 000 IU
25–50	150 000 IU	350 000 IU	500 000 IU
50–75	100 000 IU	200 000 IU	300 000 IU

Responders

13% did not respond

VitaminDWiki expects that a different form of vitamin D would have resulted in responses.
  Sublingual,Inaled, Injection topical, patch, gut friendly, etc.
   as well as adding Omega-3 and/or Magnesium

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See also VitaminDWiki

• Cystic Fibrosis Foundation recommends vitamin D dose, patients are taking even more – March 2015
• Death due to cystic fibrosis reduced about 4X due to 250000 IU of vitamin D – RCT June 2012
• Might use Vitamin D for cystic fibrosis and topically on skin – June 2011
• Cystic Fibrosis category listing has 52 items along with related searches
• Loading Dose of Vitamin D category listing has 206 items along with related searches
• Overview Loading of vitamin D
• 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015
• Vitamin D loading doses of up to 400,000 IU OK for adolescents – meta-analysis Dec 2014
• Loading dose of 300,000 IU of vitamin D does not last long – March 2014

Many ways to increase Vitamin D - click on chart for details