Vitamin d deficiency in pediatric patients with cystic fibrosis: associated risk factors in the northern United States.
South Med J. 2015 Mar;108(3):164-9. doi: 10.14423/SMJ.0000000000000254.
Lansing AH1, McDonald C1, Patel RA1, Meihls S1, Crowell K1, Chatfield B1, Pohl JF1.
Departments of Psychology, Pediatric Pulmonology, and Pediatric Gastroenterology, Primary Children's Hospital, U. of Utah School of Medicine, Salt Lake City.
Cystic fibrosis (CF) is associated with vitamin D deficiency, which can lead to adverse effects including recurrent pulmonary infections and osteoporosis. We longitudinally investigated calcifediol or 25-hydroxyvitamin D (25(OH)D) levels for our pediatric patients with CF based on the time of year as well as vitamin D supplementation dosing ranges for these patients at our CF center.
We retrospectively evaluated vitamin D deficiency in our pediatric CF center for 2 years (baseline and annually) while evaluating 25(OH)D serum changes based on vitamin D supplementation, seasonality, patient age, and other factors associated with CF.
Vitamin D supplementation was noted to be higher than current Cystic Fibrosis Foundation dosing recommendations, and no patient experienced vitamin D toxicity. Seasonality was a strong indicator of 25(OH)D levels, especially during summer or fall. Significantly fewer patients with initially low 25(OH)D levels maintained low levels at the conclusion of the study, suggesting benefit. Older patient age and higher supplemental dosing correlated with significantly lower 25(OH)D levels.
This study suggests that targeted intervention among pediatric patients with CF living in northern latitudes of the United States, especially older children, is needed to prevent vitamin D deficiency.
- Cystic Fibrosis
- A type of vitamin D by Biotics Research for mal-absorption probably works for Cystic Fibrosis as well
- Death due to cystic fibrosis reduced about 4X due to 250000 IU of vitamin D – RCT June 2012 has the following
Approx 4X less risk of death due to single dose of Vitamin D
1 person in vitamin D group died vs 5 died in the placebo group