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Powder-based Vitamin D may be gut-friendly (Cystic Fibrosis) – RCT Aug 2017

Prospective, Randomized, Double-Blind, Parallel-Group, Comparative Effectiveness Clinical Trial Comparing a Powder Vehicle Compound of Vitamin D With an Oil Vehicle Compound in Adults With Cystic Fibrosis.

JPEN J Parenter Enteral Nutr. 2017 Aug;41(6):952-958. doi: 10.1177/0148607116629673. Epub 2016 Feb 22.
Hermes WA1, Alvarez JA1, Lee MJ1, Chesdachai S1, Lodin D1, Horst R2, Tangpricha V1,3.

VitaminDWiki
Cystic Fibrosis category listing has 28 items along with related searches

Poor digestion (diabetes, Cystic Fibrosis, etc.) results in less vitamin D getting into the body
Other sources of vitamin D helps a lot for people with poor digestion

  • Many of the diseases which require 3 X larger doses of vitamin D to treat as to prevent are those which the digestion becomes worse: such as Cystic Fibrosis, Diabetes, Multiple Sclerosis, Crohn's, IBD, Celiac Disease, Parkinson's

Other forms include: Gut-friendly, Sublingual, injection, inhaled?, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
Image

And also the following

If poorly functioning gut

Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be useful – as it is water soluble
Vitamin D sprayed inside cheeks 2X more response than taken orally – Oct 2015
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Liposomal form on Amazon - Dec 2015
   $20 for 60 servings of 2500 IU - unsure why a very low-cost gut-friendly form should not be used instead
Poor guts need different forms of vitamin D has the following

Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection: Vitamin D,
or Calcidiol or Calcitriol
FastLong
10 Sun/UVSlowLong
10Topical
(skin patch/cream, vagina)
SlowNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
5Nanoemulsion
perhaps activates VDR
NormalNormal
4Sublinqual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

BACKGROUND:
There is little consensus on the most efficacious vehicle substance for vitamin D supplements. Fat malabsorption may impede the ability of patients with cystic fibrosis (CF) to absorb vitamin D in an oil vehicle. We hypothesized that vitamin D contained in a powder vehicle would be absorbed more efficiently than vitamin D contained in an oil vehicle in patients with CF.

METHODS:
In this double-blind, randomized controlled trial, hospitalized adults with CF were given a one-time bolus dose of 100,000 IU of cholecalciferol (D3) in a powder-based or oil-based vehicle. Serum D3, 25-hydroxyvitamin D, and parathyroid hormone concentrations were analyzed at 0, 12, 24, and 48 hours posttreatment. The area under the curve for serum D3 and the 12-hour time point were also assessed as indicators of D3 absorption.

RESULTS:
This trial was completed by 15 patients with CF. The median (interquartile range) age, body mass index, and forced expiratory volume in 1 second were 23.7 (19.9-33.2) years, 19.9 (18.6-22.6) kg/m2, and 63% (37%-80%), respectively. The increase in serum D3 and the area under the curve was greater in the powder group ( P = .002 and P = .036, respectively). Serum D3 was higher at 12 hours in the powder group compared with the oil group ( P = .002), although levels were similar between groups by 48 hours.

CONCLUSIONS:
In adults with CF, cholecalciferol is more efficiently absorbed in a powder compared with an oil vehicle. Physicians should consider prescribing vitamin D in a powder vehicle in patients with CF to improve the absorption of vitamin D from supplements.

PMID: 26903303 PMCID: PMC4993695 [Available on 2018-08-01]
DOI: 10.1177/0148607116629673

Created by admin. Last Modification: Monday February 5, 2018 15:55:52 UTC by admin. (Version 3)
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