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Vitamin D deficiency in cystic fibrosis - Jan 2010

Int J Endocrinol. 2010;2010:218691. Epub 2010 Jan 28.
Hall WB, Sparks AA, Aris RM.
Division of Pulmonary and Critical Care Medicine and the School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Cystic Fibrosis is the most common inherited genetic respiratory disorder in the Western World. Hypovitaminosis D is almost universal in CF patients, likely due to a combination of inadequate absorption, impaired metabolism, and lack of sun exposure. Inadequate levels are associated with the high prevalence of bone disease or osteoporosis in CF patients, which is associated with increased morbidity including fractures, kyphosis, and worsening pulmonary status. Treatment goals include regular monitoring 25 hydroxyvitamin D (25OHD) levels with aggressive treatment for those with levels <75 nmol/L (<30 ng/mL). More research is needed to determine optimal supplementation goals and strategies. PMID: 20148079 full text on-line

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