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Evidence of Vit D Benefits
Health Problems and Vit D (left column)
87 proofs that Vit D works
Intervention Trials
Meta-analysis = Trial summary
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Quality of life, healthspan
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Sources of Vitanub D
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UV- from lamps or sun
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Take Vit D3, not D2
Forms of Vit D
Getting Vitamin D into your body
Gut-friendly forms
Injection
Topical (spray and cream)
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If very poor liver - Calcidiol
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How much to take
Overview How Much vitamin D
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Reasons for Vit D deficiency
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Health Problem about 10X more likely if low Vit D
30 problems have doubled in a decade
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Vit D levels dropped by half in 20 years
22 reasons why Vit D has dropped
How often to take Vit D
Daily or weekly
Once every 2 weeks is great
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Cofactors in a nutshell
Magnesium
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What I actually take (bulk)
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World
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36
About D - introduction
115
About D - more info.
179
Books, videos on Vitamin D
366
Deficiency of Vitamin D
47
Evidence for D
653
Intervention
19
Better than daily
199
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491
Meta-analysis of Vitamin D
108
Food sources for Vitamin D
111
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91
Forms of Vitamin D
26
Calcidiol
48
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56
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94
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38
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135
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167
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39
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14
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212
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15
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87
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25
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118
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50
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12
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14
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222
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110
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272
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35
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391
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141
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170
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36
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39
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136
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195
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617
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137
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194
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23
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88
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61
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85
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356
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353
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51
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192
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138
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1
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82
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756
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56
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101
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119
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345
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97
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427
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74
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18
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97
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70
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283
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108
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472
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34
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77
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140
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150
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333
How much Vitamin D
9
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76
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400
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102
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26
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47
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92
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43
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52
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139
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51
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32
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47
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40
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162
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3
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116
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18
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29
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65
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22
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22
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226
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33
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303
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133
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76
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234
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97
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10
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24
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35
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43
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0
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29
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194
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54
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260
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332
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54
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127
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52
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111
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142
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815
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97
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40
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337
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131
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101
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14
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25
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136
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54
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111
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62
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47
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209
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Falls and Fractures
Bone density improved by monthly 50,000 IU of vitamin D for 6 months – RCT Jan 2021
Yet another low Vitamin D health problem with increased COVID-19 risks (Vertebral Fracture) – Oct 2020
1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017
1 in 4 Iranian patients did not achieve 20 ng with 3700 IU vitamin D daily for a year after fracture – Nov 2013
1000 IU minimum to decrease falls and fractures Swiss - 2009
20 percent fewer male hip fractures if more Magnesium in the water – July 2013
24 years ago hip fractures were reduced 24 percent in a large trial using Vitamin D and Ca – Oct 2016
2X fewer Senior falls in group getting 100,000 IU vitamin D monthly via Meals-on-Wheels – RCT Aug 2015
2X more falls for senior men with less than 20ng of vitamin D – April 2011
3 instead of 11 fractures with Parkinson disease when have enough sun - Nov 2010
3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020
30 percent less chance of dying after hip fracture if take vitamin D and other drugs – 2011
39% fewer falls with 2000 IU than 800 IU – RCT June 2010
400 IU of vitamin D does not prevent fractures – US Preventive Services – April 2018
400 IU of Vitamin D is too little and annual is too infrequent to prevent falls-fractures (no news) USPSTF Sept 2017
4X reduction in bone fractures following Kidney Transplant with monthly Vitamin D (100,000 IU) - RCT June 2019
75 percent of hip fractures associated with vitamin D deficiency - Jan 2011
800 IU of vitamin D does not prevent enough falls to be cost effective - July 2015
800 IU of vitamin D does not prevent falls (nope, need at least 2,000) - March 2015
800 IU vitamin D reduces falls - Dec 2009
A call to action: Vitamin D for hip fracture (50,000 weekly for 8 weeks, then bi-weekly – Holick July 2020
Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011
Acute fracture patients – 70 percent were vitamin D deficient – meta-analysis Sept 2015
Added 1 lb of muscle to sarcopenia adults in 13 weeks with just 800 IU vitamin D and protein – RCT Jan 2017
Ankle strength and vitamin D lowest in winter, and were associated with more elderly falls – May 2012
Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018
Bone fracture (low energy) 19X more likely in children if low vitamin K2 - June 2017
Bone fracture healing not a function of vitamin D level – Jan 2013
Bone fracture in children 1.8 X more likely if born in winter (low vitamin D) – Dec 2014
Bone fractures 2.8 X more likely among cancer survivors (perhaps low vitamin D) – Dec 2017
Bone fractures heal poorly with only 1,000 IU of vitamin D (not a surprise) – Sept 2017
Bone fractures healed much better if more than 20ng of vitamin D – Sept 2016
Bone fractures in children requiring surgery were 55X more likely with low vitamin D – June 2015
Bone fractures occurred twice as often if low Magnesium – April 2017
Bone fractures reduced by a minimum of 800 IU vitamin D and Calcium – meta-meta-analysis March 2014
Bone increased : Stiffness (Vitamin D), Flexibility (Vitamin K2) – Sept 2020
Bone loss (following gastric cancer) reduced by 16,000 IU of vitamin D every 10 days – Aug 2017
Bone strength (more accurate than BMD) is inversely associated with vitamin D level – May 2015
Both Calcium AND vitamin D needed to prevent elderly fractures – Sept 2010
Calcium (alone) does not reduce risk of bone fracture
Calcium by itself does not reduce risk of fractures (shown yet again) – Oct 2019
Calcium supplements proven to NOT reduce fractures, but are proven to INCREASE heart problems – July 2015
Chance of a fall decreased with vitamin D3 but increased with D2 – Oct 2011
Children with forearm fractures have lower levels of vitamin D – June 2017
Children with fracture history have lower vitamin D levels (behind paywall) – June 2016
Cochrane review finds that Vitamin D helps prevent fractures– downloaded Feb 2010
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Health Problems and D
Acne
(20+) studies)
Attention Deficit Hyperactivity Disorder
(85+)
Allergy
Overview
Amyotrophic Lateral Sclerosis
(30+)
Alzheimer's
Overview
Ankylosing Spondylitis
(15+)
Antibiotics & Pro
(84+)
Overview
Arthritis see:
Osteo
Rheum
Asthma
Overview
Atopic Dermatitis Overview
(18+)
Autism
(135+)
Overview
Autoimmune
(167+)
Back Pain
(37+)
Bipolar Disorder
(14+)
Bone - Health
(272+)
Breathing
(387+)
Burns, wounds
(30+)
Cancer
(212+)
Overview
After diagnosis
(87+)
Bladder
(25+)
Breast
(223+)
Overview
Colon
(118+)
Overview
Leukemia
(16+)
Liver
(14+)
Lung
(50+)
Overview
Lymphoma
(22+)
Other
(55+)
Ovarian
(21+)
Pancreatic
(55+)
Prostate
(94+)
Overview
Skin
(110+)
Overview
Cardiovascular
(431+)
Overview
Carpal Tunnel Syndrome
(12+)
Cerebral Palsy
(6+)
Cholesterol
(47+)
Overview Cholesterol and vitamin D
)
Chronic Fatigue
Overview
Cognitive
(293+)
Overview
Colds and flu
Overview
Concussions
(25+)
Chronic obstructive pulmonary disease
(17+)
COVID-19
(350+)
Cystic Fibrosis
(41+)
Dental
(80+)
Depression
(217+)
Diabetes
(463+)
Overview
Diseases gen.+ misc,
(93+)
Ear
(11+)
Endometriosis
(8+)
Epilepsy
(14+)
Falls/Fractures
(222+)
Overview
Fatigue, Chronic
Overview
Fertility and sperm
(101+)
Fibromyalgia
Overview
Fractures
Overview
Fraility
(16+)
Genetics
(272+)
CYP27B1
(35+)
Vit D Binding
(141+)
Vit D Receptor
(391+)
Gestational Diabetes
(34+)
Gout
(13+)
Gut
(170+)
Overview
Hair
(20+)
Headache
(34+)
Health - general
(92+)
Hepatitis-B
(9+)
Hepatitis-C
(13+)
Human Immunodeficiency Virus
(39+)
Overview
Hives
(10+)
Hypertension
(136+)
Overview
Hyperparathyroid
Overview
Immunity
(195+)
Infant-Child – moved to bottom
Inflammation
(135+)
Infection
(16+)
Influenza
Overview
Jaundice
(4+)
Kidney
(193+)
Overview
Kidney Stones
(23+)
Overview
Leprosy
(16+)
Liver
(88+)
Overview
Lupus
(60+)
Myalgic Enceph.
Overview
Mental Illness
(20+)
Mental Stress
(5+)
Metabolic Syndrome
(85+)
Overview
Migraine Headache
(4+)
Military – moved to bottom
Mortality
(200+)
Multiple Sclerosis
(356+)
Overview
Muscle
(18+)
Myopia
(17+)
Obesity
(353+)
Overview
Osteoarthritis
(51+)
Overview
Osteoporosis
(192+)
Overview
Pain - chronic
(138+)
Overview
Parkinson
(82+)
Overview
Photosensitivity
(3+)
Pneumonia
(15+)
Pollution
(31+)
Pregnancy
(756+)
Overview
Psoriasis
(55+)
Raynaud's
(4+)
Respiratory Tract Infection
(8+)
Restless Legs Syndrome
(15+)
Rheum. Arth
(101+)
Overview
Rickets
(119+)
Overview
Sarcopenia
(28+)
Schizophrenia
Overview
Seniors – moved to bottom
Sepsis
(16+)
Shingles
(15+)
Shin splints
(4+)
Sickle Cell
(17+)
Overview
Skin
(97+)
Overview
Dark
(419+)
Overview
Sleep
(74+)
Smoking
(33+)
Spinal Cord
(18+)
Spinal Surgery
(13+)
Sports – moved to bottom
Statins
(40+)
Stroke
(97+)
Overview
Suicide
(16+)
Thyroid/Parath.
(70+)
Overview
Trauma and surgery
(282+)
Tuberculosis
(108+)
Overview
Urinary Tract Infection
(15+)
Vertigo
(18+)
Virus
(470+)
Vision
(77+)
Women – moved to bottom
Youth – moved to bottom
People and Low Vitamin D
Infant-Child
(617+)
Military
(27+)
Seniors
(345+)
Overview
Sports
(234+)
Overview
Women
(140+)
Overview
Youth
(150+)
# of studies as of Jan 22, 2011