Loading...
 
Toggle Health Problems and D

Bone fractures occurred twice as often if low Magnesium – April 2017

Low serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort study

European Journal of Epidemiology, pp 1–11


 Download the PDF from VitaminDWiki
Image

Magnesium, which is an essential trace element that plays a key role in several cellular processes, is a major component of bone; however, its relationship with risk of major bone fractures is uncertain. We aimed to investigate the association of baseline serum magnesium concentrations with risk of incident fractures. We analyzed data on 2245 men aged 42–61 years in the Kuopio Ischemic Heart Disease prospective cohort study, with the assessment of serum magnesium measurements and dietary intakes made at baseline. Hazard ratios [95% confidence intervals (CI)] for incident total (femoral, humeral, and forearm) and femoral fractures were assessed. During a median follow-up of 25.6 years, 123 total fractures were recorded. Serum magnesium was non-linearly associated with risk of total fractures. In age-adjusted Cox regression analysis, the hazard ratio (HR) (95% CIs) for total fractures in a comparison of the bottom quartile versus top quartile of magnesium concentrations was 2.10 (1.30–3.41), which persisted on adjustment for several established risk factors 1.99 (1.23–3.24). The association remained consistent on further adjustment for renal function, socioeconomic status, total energy intake, and several trace elements 1.80 (1.10–2.94). The corresponding adjusted HRs for femoral fractures were 2.56 (1.38–4.76), 2.43 (1.30–4.53) and 2.13 (1.13–3.99) respectively. There was no evidence of an association of dietary magnesium intake with risk of any fractures. In middle-aged Caucasian men, low serum magnesium is strongly and independently associated with an increased risk of fractures. Further research is needed to assess the potential relevance of serum magnesium in the prevention of fractures.

Clipped from PDF

"Of the 22 men who had excess serum magnesium concentrations at baseline, none of them experienced a fracture at follow-up; "


Created by admin. Last Modification: Sunday August 26, 2018 16:21:48 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
8324 Mg fracture.jpg admin 20 Aug, 2017 15.63 Kb 573
8323 Fracture Mg.pdf admin 20 Aug, 2017 490.14 Kb 670