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Vitamin D supplementation reduces Metabolic Syndrome if deficient – Aug 2020

Mechanistic Effects of Vitamin D Supplementation on Metabolic Syndrome Components in Patients with or without Vitamin D Deficiency

Review J Obes Metab Syndr. 2020 Aug 4. doi: 10.7570/jomes20003
Samira Faraji 1 2, Mohammad Alizadeh 2 3

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MetS “ … can increase the risk of other diseases, such as a
2-fold increase in risk for cardiovascular disease
2- to 4-fold for stroke
5-fold or more for type 2 diabetes, and
3- to 4-fold for myocardial infarction.”

Metabolic Syndrome has the following

106 items

See also

Items in both categories Metabolic Syndrome and Diabetes are listed here:

Items in categories Metabolic Syndrome AND Obesity

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The prevalences of metabolic syndrome (MetS) and vitamin D deficiency are increasing dramatically worldwide. MetS in itself is not a disease but is a major challenge because it can increase the risk of most non-communicable diseases. The beneficial effect of vitamin D on MetS components remains controversial, so the present review focused on the clinical effects of vitamin D supplementation on MetS components.
Vitamin D can inhibit the protein expression of nuclear factor beta; improve arterial stiffness; decrease renin-angiotensin-aldosterone system activity, parathyroid hormone levels, inflammatory cytokines, 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA)-reductase, and lanosterol 14 β-demethylase enzyme activity; increase the activity of lipoprotein lipase; alter gene expression in C2C12 cells; and improve phospholipid metabolism and mitochondrial oxidation. We tried to elucidate and analyze almost all evidence from randomized controlled trial studies of the efficacy of vitamin D supplementation in patients with MetS. The findings of the present study reported beneficial effects of vitamin D supplementation on mentioned factors. Vitamin D supplementation is recommended in people with vitamin D deficiency even if it has no considerable effect on most MetS factors. However, existing data from interventional studies are insufficient to reach a definitive conclusion about the effect of vitamin D supplementation on MetS components in patients without vitamin D deficiency. Thus, new clinical studies are needed to test the hypothesis that vitamin D supplementation could alleviate MetS components in patients with sufficient intake of vitamin D.


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Created by admin. Last Modification: Wednesday August 5, 2020 16:16:51 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
14123 RCT MetS.jpg admin 05 Aug, 2020 715.82 Kb 328
14122 Defciency leads to MetS.jpg admin 05 Aug, 2020 117.46 Kb 380
14121 Metabolic Syndrome.pdf admin 05 Aug, 2020 984.59 Kb 390