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Postpartum depression 7X more likely if less than 10 ng of vitamin D – Sept 2014

Association between serum 25-hydroxyvitamin D levels measured 24 hours after delivery and postpartum depression.

BJOG. 2014 Sep 19. doi: 10.1111/1471-0528.13111. [Epub ahead of print]
Fu CW1, Liu JT, Tu WJ, Yang JQ, Cao Y.

To assess the possible relationship between serum levels of 25[OH]D (25-hydroxyvitamin D) collected 24 hours after delivery and postpartum depression in a Chinese cohort sample.

DESIGN: Cohort study.

SETTING: One city hospital in Beijing, China.

POPULATION: Women delivering a full-term, singleton, live-born infant at one city hospital in Beijing between August 2013 and November 2013.

METHODS: Women were enrolled immediately postpartum. A blood sample was obtained 24-48 hours after childbirth to test serum levels of 25[OH]D. Participation consisted of a visit to an obstetric unit 3 months after delivery.

MAIN OUTCOME MEASURE: At 3 months' postpartum, women were screened for depression using the Edinburgh Postnatal Depression Scale (EPDS). The primary outcome measure was a prespecified EPDS score of ≥12.

RESULTS: During the study period, 323 women were admitted. In all, 248 agreed to enrol and 213 completed 3 months' follow-up (21 were lost to follow-up and 14 withdrew). Of the 213 women who were included, 26 (12.2%) were considered to meet criteria for postpartum depression. Serum 25[OH]D levels in women with no postpartum depression were significantly higher than those in women with postpartum depression (P < 0.0001). Based on the receiver operating characteristic curve, the optimal cutoff value for serum 25[OH]D level as an indicator for screening for postpartum depression was estimated to be 10.2 ng/ml, with an area under the curve of 0.801 (95%CI 0.704-0.896). In multivariate analysis, there was an increased risk of postpartum depression associated with 25[OH]D levels ≤10.2 ng/ml (OR 7.17, 95%CI 3.81-12.94; P < 0.0001) after adjusting for possible confounders.

CONCLUSION: Our study demonstrated that lower serum 25[OH]D levels were associated with postpartum depression. This association was independent of other possible variables.
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Items tagged in both categories Depression AND Pregnancy

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Depression before or after birth - from the web

F.D.A. Approves First Drug for Postpartum Depression New York Times March 2019
"The medication works quickly, within 48 hours. But it’s an expensive infusion and requires a stay in a medical center."
60 hours of infusion >$20,000 for just the drug. Was found to be better than a placebo

Attached files

ID Name Comment Uploaded Size Downloads
9236 PPD China.jpg admin 23 Jan, 2018 19.29 Kb 641
9235 postpartum depression.pdf admin 23 Jan, 2018 150.51 Kb 1354
9234 PPD1 in 5.jpg admin 23 Jan, 2018 17.95 Kb 540