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Role and Mechanism of Vitamin D in Sepsis (Chinese) – Feb 2020

Chinese Critical Care Medicine, 31 (9), 1170-1173 Sep 2019, doi: 10.3760/cma.j.issn.2095-4352.2019.09.024
. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, Chen Yang 1, Yu Liu, Wenhui Wan wanwhnj at sina.com.
Department of Geriatrics, Eastern Theater General Hospital, Nanjing 210002, Jiangsu, China.

VitaminDWiki

Vitamin D reduces sepsis starts with
Summary of Sepsis and Vitamin D

  • Sepsis more likely in those with poor immune systems
    Infants, elderly, sick, those with low vitamin D
  • Severe Sepsis has been associated with low vitamin D in many studies
  • Vitamin D treats Sepsis (RCT- 2015, below)
      Reduced: ICU by 8 days, Hospital stay by 7 days, and readmission rate to 0%
  • Many studies have found that a high level of Vitamin D also prevents Sepsis

VitaminDWiki recommendations for Vitamin D treatment of Sepsis in ICU

  1. Fortify the immune system as fast as possible ( Vitamin D Loading dose = Stoss dose = Bolus dose )
    Vitamin D levels can be raised very quickly
    However, Injection into muscle may provide better response than a tube down the throat
  2. Speedup the restoration of Vitamin D with sublingual or topical vitamin D
  3. Follow loading dose with maintenance doses of vitamin D - probably 50,000 IU weekly
    Note: Many studies incorrectly used no maintenance dosing, just loading dose
  4. Consider reducing Sepsis even more by adding:   Omega-3    Magnesium    Glutamine


Sepsis is a life-threatening organ dysfunction caused by the host's imbalance in response to infection, which is still the leading cause of death in critically ill patients. In recent years, studies have found that vitamin D deficiency or insufficiency is common in critically ill patients, especially sepsis. The relationship between vitamin D and sepsis has attracted more and more attention.

The mechanism of vitamin D in sepsis is described from the aspects of

  • immune regulation,
  • inflammation regulation,
  • endothelial cell protection,
  • carbon monoxide regulation, and
  • receptor gene polymorphism,

by analyzing the related literatures of vitamin D and sepsis in recent years in order to provide new ideas for clinical diagnosis and treatment of sepsis.


Created by admin. Last Modification: Thursday February 27, 2020 01:16:30 GMT-0000 by admin. (Version 1)
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